Multi-Tissue Metabolome Analysis

Oscillating Compounds

Heatmaps

HFD-only Heatmap

NC-only Heatmap

Both Heatmap

Phase-Amplitude Matrices

HFD-only Matrix

NC-onlyMatrix

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Histograms

HFD-only histogram

NC-only histogram

Both histogram

Venn Diagrams

Tissue Comparisons

Download Compound Labels

Metabolite Pathway Enrichment Analysis

Please select a condition.

Pathway	hits	oddsratio	pvalue
Purine metabolism	C00301	18.1590909091	0.103732578031

Pathway	hits	oddsratio	pvalue
Alpha linolenic acid and linoleic acid metabolism	C03242	16.6458333333	0.0751434218687
Lysine degradation	C00956	11.0972222222	0.106453788847
Glutaric aciduria type iii	C00956	10.2435897436	0.114090935951

Pathway	hits	oddsratio	pvalue
Pyrimidine metabolism	C00106,C00055,C00475,C00881	6.2421875	0.0080606800281
Glutathione metabolism	C00025,C01879	12.484375	0.0182536096125
5-oxoprolinuria	C01879	inf	0.0208333333333
Gout or kelley-seegmiller syndrome	C00366	inf	0.0208333333333
Lesch-nyhan syndrome (lns)	C00366	inf	0.0208333333333
Molybdenium cofactor deficiency	C00262	49.9375	0.0412076703387
Xanthine dehydrogenase deficiency (xanthinuria)	C00262	49.9375	0.0412076703387
Ump synthase deiciency (orotic aciduria)	C00106	49.9375	0.0412076703387
Glutathione synthetase deficiency	C01879	24.96875	0.0611336722999
Mngie (mitochondrial neurogastrointestinal encephalopathy)	C00106	12.484375	0.0996820211489
Transcription/translation	C00025,C00055	3.84134615385	0.117322669879
Taurine and hypotaurine metabolism	C00519	8.32291666667	0.136558581944
Alanine metabolism	C00025	8.32291666667	0.136558581944
Cysteine metabolism	C00025	7.13392857143	0.154393945379
Malate-aspartate shuttle	C00025	7.13392857143	0.154393945379
Riboflavin metabolism	C00255	6.2421875	0.17183970136
Hartnup disorder	C00025	6.2421875	0.17183970136
Vitamin b6 metabolism	C00847	5.54861111111	0.188904822666
Phosphatidylinositol phosphate metabolism	C00055	4.99375	0.205598064814
Glucose-alanine cycle	C00025	4.53977272727	0.221927971584
Beta-alanine metabolism	C00106	4.16145833333	0.23790288038
Purine metabolism	C00366,C00262	2.3226744186	0.241734219685
Glutamate metabolism	C00025	2.9375	0.312730465165
Ammonia recycling	C00025	2.9375	0.312730465165
Urea cycle	C00025	2.62828947368	0.340446655254
2-hydroxyglutric aciduria (d and l form)	C00025	2.496875	0.353858625183
Histidine metabolism	C00025	2.17119565217	0.392389960596
Prolidase deficiency(pd)	C00025	2.08072916667	0.404686830442
Arginine and proline metabolism	C00025	1.9975	0.416720509255

Pathway	hits	oddsratio	pvalue
Gout or kelley-seegmiller syndrome	C00366	inf	0.0111386138614
Lesch-nyhan syndrome (lns)	C00366	inf	0.0111386138614
Ump synthase deiciency (orotic aciduria)	C00106	99.875	0.0221395439915
Mngie (mitochondrial neurogastrointestinal encephalopathy)	C00106	24.96875	0.0543347918963
Purine metabolism	C00366,C00301	4.64534883721	0.0937204918122
Alpha linolenic acid and linoleic acid metabolism	C00219	12.484375	0.095444541091
Pantothenate and coa biosynthesis	C00882	11.0972222222	0.10540904431
Beta-alanine metabolism	C00106	8.32291666667	0.134578181788
Pyrimidine metabolism	C00106	2.85357142857	0.32612310946
Arachidonic acid metabolism	C00219	2.77430555556	0.333309000474

Pathway	hits	oddsratio	pvalue
Lysinuric protein intolerance	C00062,C00047	inf	0.000275692412097
Hartnup disorder	C00062,C00047	19.0238095238	0.00910810405458
Transcription/translation	C00062,C00047,C00144	7.99	0.0115869449956
Lysine degradation	C00047,C00956	12.1060606061	0.0188016811747
Glutaric aciduria type iii	C00047,C00956	11.0972222222	0.0216730667311
Carnitine synthesis	C00042,C00047	8.87777777778	0.031248324016
Saccharopinuria/hyperlysinemia ii	C00047	66.5833333333	0.0317440120215
Glutamate metabolism	C00042,C00144	8.32291666667	0.034738268273
Argininemia	C00062	33.2916666667	0.0472075597411
Argininosuccinic aciduria	C00062	22.1944444444	0.0624054759661
Biotin metabolism	C00047	22.1944444444	0.0624054759661
Biotinidase deficiency	C00047	22.1944444444	0.0624054759661
Citrullinemia type i	C00047	13.3166666667	0.0920238500334
Alpha linolenic acid and linoleic acid metabolism	C03242	8.32291666667	0.134578181788
Purine metabolism	C00387,C00144	3.09689922481	0.164791786401
Phytanic acid peroxisomal oxidation	C00042	4.75595238095	0.213381505792
Mitochondrial electron transport chain	C00042	4.75595238095	0.213381505792
Urea cycle	C00062	3.50438596491	0.273154355339
2-hydroxyglutric aciduria (d and l form)	C00042	3.32916666667	0.284511318536
Citric acid cycle	C00042	3.02651515152	0.306656057913
Prolidase deficiency(pd)	C00062	2.77430555556	0.328064440184
Arginine and proline metabolism	C00062	2.66333333333	0.338500715306

Pathway	hits	oddsratio	pvalue
Molybdenium cofactor deficiency	C00385,C00262	inf	0.00161891679749
Xanthine dehydrogenase deficiency (xanthinuria)	C00385,C00262	inf	0.00161891679749
Pyrimidine metabolism	C00239,C00299,C00055,C00214,C00475,C00881	4.99375	0.00349816865602
5-oxoprolinuria	C01879	inf	0.0396634615384
Riboflavin metabolism	C00061,C00255	7.13392857143	0.0479113552587
Glutathione metabolism	C00025,C01879	6.2421875	0.0582662975447
Glutathione synthetase deficiency	C01879	12.484375	0.114201574376
Glutamate metabolism	C00025,C00357	3.12109375	0.15976035294
Mngie (mitochondrial neurogastrointestinal encephalopathy)	C00214	6.2421875	0.182793025109
Taurine and hypotaurine metabolism	C00519	4.16145833333	0.245925044427
Alanine metabolism	C00025	4.16145833333	0.245925044427
Sulfate/sulfite metabolism	C00054	4.16145833333	0.245925044427
Purine metabolism	C00262,C00130,C00385	1.78348214286	0.265847272264
Cysteine metabolism	C00025	3.56696428571	0.275584726828
Malate-aspartate shuttle	C00025	3.56696428571	0.275584726828
Hartnup disorder	C00025	3.12109375	0.304043898274
Transcription/translation	C00025,C00055	1.92067307692	0.305159356417
Vitamin b6 metabolism	C00847	2.77430555556	0.331352520577
Phosphatidylinositol phosphate metabolism	C00055	2.496875	0.357558419413
Glucose-alanine cycle	C00025	2.26988636364	0.382707378084
Sphingolipid metabolism	C00346	1.78348214286	0.452241662671
Amino sugar metabolism	C00357	1.78348214286	0.452241662671
Pentose phosphate pathway	C00345	1.46875	0.513733651063
Ammonia recycling	C00025	1.46875	0.513733651063
Urea cycle	C00025	1.31414473684	0.550736547187
2-hydroxyglutric aciduria (d and l form)	C00025	1.2484375	0.568137596415
Histidine metabolism	C00025	1.08559782609	0.616291687208
Prolidase deficiency(pd)	C00025	1.04036458333	0.631084180576
Arginine and proline metabolism	C00025	0.99875	0.645289807227

Pathway	hits	oddsratio	pvalue
Alpha linolenic acid and linoleic acid metabolism	C03242,C00219	12.015037594	0.019869196468
Gout or kelley-seegmiller syndrome	C00366	inf	0.02442002442
Lesch-nyhan syndrome (lns)	C00366	inf	0.02442002442
Ump synthase deiciency (orotic aciduria)	C00106	42.0526315789	0.0482146579708
Purine metabolism	C00366,C01762,C00301	3.0037593985	0.101927130095
Mngie (mitochondrial neurogastrointestinal encephalopathy)	C00106	10.5131578947	0.116011465968
Pantothenate and coa biosynthesis	C00882	4.67251461988	0.217973545919
Betaine metabolism	C00719	4.67251461988	0.217973545919
Pyrimidine metabolism	C00106,C00055	2.47368421053	0.220396220149
Phosphatidylinositol phosphate metabolism	C00055	4.20526315789	0.236840287874
Beta-alanine metabolism	C00106	3.50438596491	0.273154355339
Sphingolipid metabolism	C00346	3.0037593985	0.307658380568
Phytanic acid peroxisomal oxidation	C00042	3.0037593985	0.307658380568
Mitochondrial electron transport chain	C00042	3.0037593985	0.307658380568
Carnitine synthesis	C00042	2.62828947368	0.340446655254
Glutamate metabolism	C00042	2.47368421053	0.356225443406
2-hydroxyglutric aciduria (d and l form)	C00042	2.10263157895	0.401227794006
Citric acid cycle	C00042	1.91148325359	0.429384767965
Methionine metabolism	C00719	1.82837528604	0.44293857395
Glycine, serine and threonine metabolism	C00719	1.68210526316	0.469042069063
Transcription/translation	C00055	1.55750487329	0.493864224213
Arachidonic acid metabolism	C00219	1.16812865497	0.591389678211

Pathway	hits	oddsratio	pvalue
Transcription/translation	C00078,C00079,C00062,C00144,C00047,C00188	18.1590909091	1.11571599011e-05
Lysinuric protein intolerance	C00062,C00047	inf	0.000275692412097
Hartnup disorder	C00062,C00047	19.0238095238	0.00910810405458
Lysine degradation	C00047,C00956	12.1060606061	0.0188016811747
Glutaric aciduria type iii	C00047,C00956	11.0972222222	0.0216730667311
Tyrosinemia type 3 (tyro3)	C00079	66.5833333333	0.0317440120215
Tyrosinemia type 2 (or richner-hanhart syndrome)	C00079	66.5833333333	0.0317440120215
Saccharopinuria/hyperlysinemia ii	C00047	66.5833333333	0.0317440120215
Argininemia	C00062	33.2916666667	0.0472075597411
Argininosuccinic aciduria	C00062	22.1944444444	0.0624054759661
Biotin metabolism	C00047	22.1944444444	0.0624054759661
Biotinidase deficiency	C00047	22.1944444444	0.0624054759661
Phenylketonuria	C00079	16.6458333333	0.0773426436283
Citrullinemia type i	C00047	13.3166666667	0.0920238500334
Purine metabolism	C00387,C00144	3.09689922481	0.164791786401
Phenylalanine and tyrosine metabolism	C00079	5.54861111111	0.188008330034
Carnitine synthesis	C00047	4.16145833333	0.23790288038
Glutamate metabolism	C00144	3.91666666667	0.249853739916
Urea cycle	C00062	3.50438596491	0.273154355339
Citric acid cycle	C00417	3.02651515152	0.306656057913
Prolidase deficiency(pd)	C00062	2.77430555556	0.328064440184
Glycine, serine and threonine metabolism	C00188	2.66333333333	0.338500715306
Arginine and proline metabolism	C00062	2.66333333333	0.338500715306
Tryptophan metabolism	C00078	2.01767676768	0.415968715861

Pathway	hits	oddsratio	pvalue
Molybdenium cofactor deficiency	C00385,C00262	inf	0.00266551705677
Xanthine dehydrogenase deficiency (xanthinuria)	C00385,C00262	inf	0.00266551705677
Pyrimidine metabolism	C00239,C00214,C00475,C00881,C00299	3.06835637481	0.0382721138327
5-oxoprolinuria	C01879	inf	0.0510688836104
Glycerol kinase deficiency	C00116	inf	0.0510688836104
Riboflavin metabolism	C00061,C00255	5.43537414966	0.0748004126815
Glutathione metabolism	C00025,C01879	4.75595238095	0.0903051775683
Iminoglycinuria	C00148	19.0238095238	0.0994722501641
Prolinemia type ii	C00148	19.0238095238	0.0994722501641
Hyperprolinemia type i	C00148	9.5119047619	0.145352218462
Glutathione synthetase deficiency	C01879	9.5119047619	0.145352218462
Hyperprolinemia type ii	C00148	6.34126984127	0.188843170658
Purine metabolism	C00262,C00130,C00147,C00385	1.85598141696	0.200358444529
Fatty acid biosynthesis	C01089,C06424,C02679	1.96798029557	0.224924054929
Mngie (mitochondrial neurogastrointestinal encephalopathy)	C00214	4.75595238095	0.230072182078
Glutamate metabolism	C00025,C00357	2.37797619048	0.234193766912
2-hydroxyglutric aciduria (d and l form)	C00025,C01089	2.00250626566	0.291382994986
Taurine and hypotaurine metabolism	C00519	3.17063492063	0.306218559518
Alanine metabolism	C00025	3.17063492063	0.306218559518
Sulfate/sulfite metabolism	C00054	3.17063492063	0.306218559518
Cysteine metabolism	C00025	2.71768707483	0.341357077705
Malate-aspartate shuttle	C00025	2.71768707483	0.341357077705
Prolidase deficiency(pd)	C00025,C00148	1.65424430642	0.366234167015
Spermidine and spermine biosynthesis	C00750	2.37797619048	0.374676660832
Hartnup disorder	C00025	2.37797619048	0.374676660832
Arginine and proline metabolism	C00025,C00148	1.58531746032	0.384451074692
Vitamin b6 metabolism	C00847	2.11375661376	0.406273492307
Ketone body metabolism	C01089	2.11375661376	0.406273492307
Transcription/translation	C00025,C00148	1.46336996337	0.420102751151
Glucose-alanine cycle	C00025	1.72943722944	0.46465795504
Nicotinate and nicotinamide metabolism	C00153	1.58531746032	0.491613116555
Beta oxidation of very long chain fatty acids	C02679	1.46336996337	0.517181111862
Amino sugar metabolism	C00357	1.35884353741	0.541434864421
Pentose phosphate pathway	C00345	1.11904761905	0.606982461509
Ammonia recycling	C00025	1.11904761905	0.606982461509
Phospholipid biosynthesis	C00307	1.05687830688	0.626633338434
Glycerolipid metabolism	C00116	1.05687830688	0.626633338434
Urea cycle	C00025	1.00125313283	0.645279989359
Histidine metabolism	C00025	0.827122153209	0.710831816983
Galactose metabolism	C00116	0.792658730159	0.725190052399

Pathway	hits	oddsratio	pvalue
Pantothenate and coa biosynthesis	C00010,C01134,C00882,C00097	23.1594202899	0.00016247442585
Galactose metabolism	C00159,C01835,C00029,C00052	6.61697722567	0.0065590822245
Nucleotide sugars metabolism	C00029,C00052	9.92546583851	0.0274962945456
Hartnup disorder	C00047,C00183	9.92546583851	0.0274962945456
Glutaric aciduria type i	C00489	inf	0.0291616038882
Gamma-glutamyltransferase deficiency	C00051	inf	0.0291616038882
Glutathione metabolism	C00051,C00097	8.6847826087	0.0336663073396
Lactose synthesis	C00029,C00052	7.71980676329	0.0403078977421
Transcription/translation	C00047,C00183,C00097	4.16869565217	0.0500947105166
Beta-alanine metabolism	C00010,C00106	6.3162055336	0.0548669078543
Hypermethioninemia	C00097	34.7391304348	0.0574384503769
Lysinuric protein intolerance	C00047	34.7391304348	0.0574384503769
Saccharopinuria/hyperlysinemia ii	C00047	34.7391304348	0.0574384503769
Ump synthase deiciency (orotic aciduria)	C00106	34.7391304348	0.0574384503769
Glutaric aciduria type iii	C00489,C00047	5.78985507246	0.062719292017
Glutathione synthetase deficiency	C00051	17.3695652174	0.0848584227297
Insulin signalling	C00010,C00029	4.08695652174	0.106554179532
Biotin metabolism	C00047	11.5797101449	0.111448492771
Biotinidase deficiency	C00047	11.5797101449	0.111448492771
Phenylacetate metabolism	C00010	8.6847826087	0.137234751748
Mngie (mitochondrial neurogastrointestinal encephalopathy)	C00106	8.6847826087	0.137234751748
Citric acid cycle	C00010,C00016	3.30848861284	0.145632641109
Citrullinemia type i	C00047	6.94782608696	0.162242440103
Taurine and hypotaurine metabolism	C00097	5.78985507246	0.186495976216
Pyruvaldehyde degradation	C00051	5.78985507246	0.186495976216
Cysteine metabolism	C00097	4.96273291925	0.210018984133
Glycerol phosphate shuttle	C00016	4.96273291925	0.210018984133
Riboflavin metabolism	C00016	4.34239130435	0.232834320331
Butyrate metabolism	C00010	4.34239130435	0.232834320331
Ketone body metabolism	C00010	3.85990338164	0.254964099552
Pyrimidine metabolism	C00106,C00299	2.04347826087	0.282593434058
2-oxobutanoate degradation	C00010	2.89492753623	0.317450634257
Lysine degradation	C00047	2.89492753623	0.317450634257
Oxidation of branched chain fatty acids	C00010	2.67224080268	0.33704535289
Beta oxidation of very long chain fatty acids	C00010	2.67224080268	0.33704535289
Starch and sucrose metabolism	C00029	2.67224080268	0.33704535289
Ethanol degradation	C00010	2.48136645963	0.356054805137
Transfer of acetyl groups into mitochondria	C00010	2.31594202899	0.37449714962
Carnitine synthesis	C00047	2.17119565217	0.392389960596
Glutamate metabolism	C00051	2.04347826087	0.409750247437
Fructose and mannose degradation	C00159	2.04347826087	0.409750247437
Propanoate metabolism	C00183	2.04347826087	0.409750247437
Methionine metabolism	C00097	1.51039697543	0.503614916727
Glycine, serine and threonine metabolism	C00097	1.38956521739	0.531330699651
Fatty acid metabolism	C00010	1.24068322981	0.569919416887
Fatty acid biosynthesis	C06424	1.1206171108	0.60520985868
Valine, leucine and isoleucine degradation	C00183	0.992546583851	0.647634230862
Bile acid biosynthesis	C00010	0.723731884058	0.755584241952

Pathway	hits	oddsratio	pvalue
Transcription/translation	C00148,C00079,C00064,C00188	12.1060606061	0.00106034425385
Oxidation of branched chain fatty acids	C03017,C00318	12.1060606061	0.0188016811747
Tyrosinemia type 3 (tyro3)	C00079	72.6363636364	0.0293562044062
Tyrosinemia type 2 (or richner-hanhart syndrome)	C00079	72.6363636364	0.0293562044062
Iminoglycinuria	C00148	72.6363636364	0.0293562044062
Prolinemia type ii	C00148	72.6363636364	0.0293562044062
Hyperprolinemia type i	C00148	36.3181818182	0.0436830500977
Hyperprolinemia type ii	C00148	24.2121212121	0.0577810886712
Phenylacetate metabolism	C00064	18.1590909091	0.0716542505557
Phenylketonuria	C00079	18.1590909091	0.0716542505557
Citrullinemia type i	C00064	14.5272727273	0.0853063939299
Pyruvaldehyde degradation	C03451	12.1060606061	0.0987413061366
Ornithine transcarbamylase deficiency (otc deficiency)	C00064	12.1060606061	0.0987413061366
Nucleotide sugars metabolism	C00668	9.07954545455	0.124974240526
Betaine metabolism	C00114	8.07070707071	0.137779495542
Phenylalanine and tyrosine metabolism	C00079	6.05303030303	0.174992433968
Beta oxidation of very long chain fatty acids	C00318	5.58741258741	0.187007107259
Starch and sucrose metabolism	C00668	5.58741258741	0.187007107259
Carnitine synthesis	C00318	4.53977272727	0.221927971583
Pentose phosphate pathway	C00668	4.27272727273	0.233204377793
Glutamate metabolism	C00064	4.27272727273	0.233204377793
Ammonia recycling	C00064	4.27272727273	0.233204377793
Phospholipid biosynthesis	C00114	4.03535353535	0.244303952541
Inositol metabolism	C00668	4.03535353535	0.244303952541
Urea cycle	C00064	3.82296650718	0.255229678528
Inositol phosphate metabolism	C00668	3.82296650718	0.255229678528
Pyruvate metabolism	C03451	3.82296650718	0.255229678528
Leigh syndrome	C03451	3.82296650718	0.255229678528
Glycolysis	C00668	3.63181818182	0.265984484614
Methionine metabolism	C00114	3.1581027668	0.297251886072
Prolidase deficiency(pd)	C00148	3.02651515152	0.307351260164
Galactose metabolism	C00668	3.02651515152	0.307351260164
Glycine, serine and threonine metabolism	C00188	2.90545454545	0.317293586573
Arginine and proline metabolism	C00148	2.90545454545	0.317293586573
Gluconeogenesis	C00668	2.79370629371	0.327081492142
Pyrimidine metabolism	C00064	2.07532467532	0.408634552416
Purine metabolism	C00064	1.65082644628	0.479588321125

Pathway	hits	oddsratio	pvalue
Ornithine transcarbamylase deficiency (otc deficiency)	C00077,C00327	15.98	0.0131246002669
Renal glucosuria	C00031	inf	0.0256097560976
Ornithine aminotransferase deficiency (oat deficiency)	C00077	inf	0.0256097560976
Glucose-alanine cycle	C00003,C00031	7.99	0.0376241020499
Glycogen storage disease type 1a (gsd1a) or von gierke ddisease	C00031	39.95	0.0505332580731
Transfer of acetyl groups into mitochondria	C00003,C00031	5.70714285714	0.0636253331292
Urea cycle	C00077,C00327	4.43888888889	0.0937897420284
Hyperprolinemia type ii	C00077	13.3166666667	0.098397746735
Argininosuccinic aciduria	C00327	13.3166666667	0.098397746735
Gliclazide pathway	C00031	13.3166666667	0.098397746735
Glibenclamide pathway	C00031	13.3166666667	0.098397746735
Glycolysis	C00003,C00031	4.20526315789	0.101841691009
Prolidase deficiency(pd)	C00077,C00327	3.47391304348	0.135615721476
Citrullinemia type i	C00327	7.99	0.143740461996
Arginine and proline metabolism	C00077,C00327	3.32916666667	0.144380526155
Gluconeogenesis	C00003,C00031	3.196	0.153248104902
Lactose degradation	C00031	5.70714285714	0.186699971538
Glycerol phosphate shuttle	C00003	5.70714285714	0.186699971538
Lactose intolerance	C00031	5.70714285714	0.186699971538
Malate-aspartate shuttle	C00003	5.70714285714	0.186699971538
Alpha linolenic acid and linoleic acid metabolism	C00219	4.99375	0.207327146172
Riboflavin metabolism	C00255	4.99375	0.207327146172
Spermidine and spermine biosynthesis	C00077	4.99375	0.207327146172
Hartnup disorder	C00407	4.99375	0.207327146172
Vitamin b6 metabolism	C00847	4.43888888889	0.227406916897
Ketone body metabolism	C00003	4.43888888889	0.227406916897
Lactose synthesis	C00031	3.995	0.246954452734
Aspartate metabolism	C00327	3.63181818182	0.265984484614
Nicotinate and nicotinamide metabolism	C00003	3.32916666667	0.284511318536
2-oxobutanoate degradation	C00003	3.32916666667	0.284511318536
Lysine degradation	C00956	3.32916666667	0.284511318536
Oxidation of branched chain fatty acids	C02571	3.07307692308	0.302548848321
Beta oxidation of very long chain fatty acids	C02571	3.07307692308	0.302548848321
Glutaric aciduria type iii	C00956	3.07307692308	0.302548848321
Ethanol degradation	C00003	2.85357142857	0.320110567968
Mitochondrial electron transport chain	C00003	2.85357142857	0.320110567968
Carnitine synthesis	C00003	2.496875	0.353858625183
Glutamate metabolism	C00003	2.35	0.370070057527
Ammonia recycling	C00003	2.35	0.370070057527
Insulin signalling	C00031	2.21944444444	0.385855891406
Glycerolipid metabolism	C00003	2.21944444444	0.385855891406
Hypoacetylaspartia	C02571	2.10263157895	0.401227794006
Citric acid cycle	C00003	1.81590909091	0.444971644849
Histidine metabolism	C00003	1.73695652174	0.45879797398
Galactose metabolism	C00031	1.66458333333	0.472263901169
Transcription/translation	C00407	1.47962962963	0.510595985396
Tryptophan metabolism	C01717	1.21060606061	0.578769613385
Pyrimidine metabolism	C00881	1.14142857143	0.599219337072
Valine, leucine and isoleucine degradation	C00407	1.14142857143	0.599219337072
Arachidonic acid metabolism	C00219	1.10972222222	0.609051572962
Purine metabolism	C00294	0.907954545455	0.679168166907

Pathway	hits	oddsratio	pvalue
Transcription/translation	C00148,C00073,C00407,C00047,C00188,C00183,C00097	8.59139784946	0.000113814598854
Pantothenate and coa biosynthesis	C00010,C01134,C00882,C00097	17.1827956989	0.000445665830761
Hypermethioninemia	C00073,C00097	inf	0.00152735351291
Galactose metabolism	C01835,C00159,C00029,C00052,C00668	6.4435483871	0.0028700617109
Nucleotide sugars metabolism	C00029,C00052,C00668	12.8870967742	0.00432890704034
Hartnup disorder	C00047,C00407,C00183	12.8870967742	0.00432890704034
Glycine n-methyltransferase deficiency	C00073	inf	0.0385078219013
Glutaric aciduria type i	C00489	inf	0.0385078219013
Gamma-glutamyltransferase deficiency	C00051	inf	0.0385078219013
Methionine adenosyltransferase deficiency	C00073	inf	0.0385078219013
Glutathione metabolism	C00051,C00097	6.4435483871	0.0553086850208
Lactose synthesis	C00029,C00052	5.72759856631	0.065824640661
Methylenetetrahydrofolate reductase deficiency (mthfrd)	C00073	25.7741935484	0.0754882902897
Lysinuric protein intolerance	C00047	25.7741935484	0.0754882902897
Iminoglycinuria	C00148	25.7741935484	0.0754882902897
Saccharopinuria/hyperlysinemia ii	C00047	25.7741935484	0.0754882902897
Prolinemia type ii	C00148	25.7741935484	0.0754882902897
Ump synthase deiciency (orotic aciduria)	C00106	25.7741935484	0.0754882902897
Beta-alanine metabolism	C00010,C00106	4.6862170088	0.088546273056
Oxidation of branched chain fatty acids	C00010,C02571	4.29569892473	0.100628719708
Beta oxidation of very long chain fatty acids	C00010,C02571	4.29569892473	0.100628719708
Starch and sucrose metabolism	C00029,C00668	4.29569892473	0.100628719708
Glutaric aciduria type iii	C00489,C00047	4.29569892473	0.100628719708
Hyperprolinemia type i	C00148	12.8870967742	0.111003746125
Glutathione synthetase deficiency	C00051	12.8870967742	0.111003746125
Cystathionine beta-synthase deficiency	C00073	12.8870967742	0.111003746125
Hyperprolinemia type ii	C00148	8.59139784946	0.14511391414
Biotin metabolism	C00047	8.59139784946	0.14511391414
Biotinidase deficiency	C00047	8.59139784946	0.14511391414
Insulin signalling	C00010,C00029	3.03225806452	0.166149762653
Phenylacetate metabolism	C00010	6.4435483871	0.177876015633
Mngie (mitochondrial neurogastrointestinal encephalopathy)	C00106	6.4435483871	0.177876015633
Citrullinemia type i	C00047	5.15483870968	0.209344876279
Citric acid cycle	C00010,C00016	2.45468509985	0.222146504722
Methionine metabolism	C00073,C00097	2.3431085044	0.236354836133
Taurine and hypotaurine metabolism	C00097	4.29569892473	0.239573029157
Pyruvaldehyde degradation	C00051	4.29569892473	0.239573029157
Glycine, serine and threonine metabolism	C00188,C00097	2.14784946237	0.264832013276
Cysteine metabolism	C00097	3.68202764977	0.268610813247
Glycerol phosphate shuttle	C00016	3.68202764977	0.268610813247
Riboflavin metabolism	C00016	3.22177419355	0.296506467569
Spermidine and spermine biosynthesis	C00073	3.22177419355	0.296506467569
Butyrate metabolism	C00010	3.22177419355	0.296506467569
Betaine metabolism	C00073	2.86379928315	0.323306221186
Ketone body metabolism	C00010	2.86379928315	0.323306221186
2-oxobutanoate degradation	C00010	2.14784946237	0.397563999551
Lysine degradation	C00047	2.14784946237	0.397563999551
Pyrimidine metabolism	C00106,C00299	1.51612903226	0.403410167651
Valine, leucine and isoleucine degradation	C00407,C00183	1.51612903226	0.403410167651
Ethanol degradation	C00010	1.84101382488	0.442354328062
Transfer of acetyl groups into mitochondria	C00010	1.71827956989	0.463447308561
Carnitine synthesis	C00047	1.61088709677	0.483718484625
Pentose phosphate pathway	C00668	1.51612903226	0.50320080596
Glutamate metabolism	C00051	1.51612903226	0.50320080596
Fructose and mannose degradation	C00159	1.51612903226	0.50320080596
Propanoate metabolism	C00183	1.51612903226	0.50320080596
Inositol metabolism	C00668	1.43189964158	0.521925863921
Inositol phosphate metabolism	C00668	1.35653650255	0.539923949044
Hypoacetylaspartia	C02571	1.35653650255	0.539923949044
Glycolysis	C00668	1.28870967742	0.557224106072
Prolidase deficiency(pd)	C00148	1.07392473118	0.619985630051
Arginine and proline metabolism	C00148	1.03096774194	0.634191774722
Gluconeogenesis	C00668	0.991315136476	0.647850891652
Fatty acid metabolism	C00010	0.920506912442	0.673613867414
Fatty acid biosynthesis	C06424	0.831425598335	0.708669610511
Bile acid biosynthesis	C00010	0.536962365591	0.845822354304

Pathway	hits	oddsratio	pvalue
Betaine metabolism	C00114,C00719,C00019	17.1214285714	0.00197603367275
Methionine metabolism	C00114,C00170,C00719,C00019	7.99	0.00367502906044
Glutamate metabolism	C00025,C00064,C00127	7.99	0.0113100652078
Spermidine and spermine biosynthesis	C00019,C00170	11.4142857143	0.0216825744579
Glutathione metabolism	C00025,C00127	9.9875	0.0266092096542
Transcription/translation	C00025,C00079,C00064	4.794	0.0367865393928
Oxidation of branched chain fatty acids	C03017,C00318	6.65833333333	0.050023431334
Tyrosinemia type 3 (tyro3)	C00079	39.95	0.0505332580731
Tyrosinemia type 2 (or richner-hanhart syndrome)	C00079	39.95	0.0505332580731
Molybdenium cofactor deficiency	C00385	39.95	0.0505332580731
S-adenosylhomocysteine (sah) hydrolase deficiency	C00019	39.95	0.0505332580731
Xanthine dehydrogenase deficiency (xanthinuria)	C00385	39.95	0.0505332580731
Carnitine synthesis	C00019,C00318	5.32666666667	0.0708249186685
Ammonia recycling	C00025,C00064	4.99375	0.0782642753511
Urea cycle	C00025,C00064	4.43888888889	0.0937897420284
Thiamine metabolism	C00378	13.3166666667	0.098397746735
Purine metabolism	C00385,C00387,C00064	2.85357142857	0.112781372354
Phenylacetate metabolism	C00064	9.9875	0.121375474063
Phenylketonuria	C00079	9.9875	0.121375474063
Citrullinemia type i	C00064	7.99	0.143740461996
Glycine, serine and threonine metabolism	C00719,C00597	3.32916666667	0.144380526155
Pyruvaldehyde degradation	C03451	6.65833333333	0.165509772284
Alanine metabolism	C00025	6.65833333333	0.165509772284
Ornithine transcarbamylase deficiency (otc deficiency)	C00064	6.65833333333	0.165509772284
Cysteine metabolism	C00025	5.70714285714	0.186699971538
Malate-aspartate shuttle	C00025	5.70714285714	0.186699971538
Hartnup disorder	C00025	4.99375	0.207327146172
Glucose-alanine cycle	C00025	3.63181818182	0.265984484614
Phenylalanine and tyrosine metabolism	C00079	3.32916666667	0.284511318536
Beta oxidation of very long chain fatty acids	C00318	3.07307692308	0.302548848321
Catecholamine biosynthesis	C00019	2.85357142857	0.320110567968
Phospholipid biosynthesis	C00114	2.21944444444	0.385855891406
Glycerolipid metabolism	C00597	2.21944444444	0.385855891406
Pyruvate metabolism	C03451	2.10263157895	0.401227794006
Leigh syndrome	C03451	2.10263157895	0.401227794006
Glycolysis	C00597	1.9975	0.416197099156
2-hydroxyglutric aciduria (d and l form)	C00025	1.9975	0.416197099156
Histidine metabolism	C00025	1.73695652174	0.45879797398
Prolidase deficiency(pd)	C00025	1.66458333333	0.472263901169
Arginine and proline metabolism	C00025	1.598	0.485379236169
Gluconeogenesis	C00597	1.53653846154	0.498153510448
Pyrimidine metabolism	C00064	1.14142857143	0.599219337072
Bile acid biosynthesis	C05465	0.832291666667	0.709157707327

Pathway	hits	oddsratio	pvalue
Ornithine transcarbamylase deficiency (otc deficiency)	C00041,C00077,C00327	21.4017857143	0.00147436000659
Urea cycle	C00086,C00041,C00327,C00077	7.13392857143	0.00532140469818
Glucose-alanine cycle	C00041,C00003,C00031	9.5119047619	0.00802525521278
Citrullinemia type i	C00041,C00327	14.2678571429	0.0171986609035
Glycerol phosphate shuttle	C00093,C00003	9.5119047619	0.030553959342
Lactic acidemia	C00041	inf	0.0350241545894
Renal glucosuria	C00031	inf	0.0350241545894
Ornithine aminotransferase deficiency (oat deficiency)	C00077	inf	0.0350241545894
Prolidase deficiency(pd)	C00086,C00327,C00077	3.89123376623	0.0583061314749
Arginine and proline metabolism	C00086,C00327,C00077	3.72204968944	0.0641310733164
Glycogen storage disease type 1a (gsd1a) or von gierke ddisease	C00031	28.5357142857	0.0687808488197
Mitochondrial electron transport chain	C00093,C00003	4.39010989011	0.0966705979841
Pyruvate carboxylase deficiency	C00041	14.2678571429	0.101317421572
Transfer of acetyl groups into mitochondria	C00003,C00031	4.07653061224	0.107875666018
Hyperprolinemia type ii	C00077	9.5119047619	0.132679388809
Argininosuccinic aciduria	C00327	9.5119047619	0.132679388809
Gliclazide pathway	C00031	9.5119047619	0.132679388809
Glibenclamide pathway	C00031	9.5119047619	0.132679388809
Glycerolipid metabolism	C00093,C00003	3.35714285714	0.143192453703
Glycolysis	C00003,C00031	3.0037593985	0.167811920498
Taurine and hypotaurine metabolism	C00519	4.75595238095	0.220146971147
Alanine metabolism	C00041	4.75595238095	0.220146971147
Gluconeogenesis	C00003,C00031	2.28285714286	0.244357405395
Lactose degradation	C00031	4.07653061224	0.247231687119
Lactose intolerance	C00031	4.07653061224	0.247231687119
Malate-aspartate shuttle	C00003	4.07653061224	0.247231687119
Transcription/translation	C00055,C00041	2.19505494505	0.25726803103
Alpha linolenic acid and linoleic acid metabolism	C00219	3.56696428571	0.273344463523
Riboflavin metabolism	C00255	3.56696428571	0.273344463523
Spermidine and spermine biosynthesis	C00077	3.56696428571	0.273344463523
Hartnup disorder	C00041	3.56696428571	0.273344463523
Vitamin b6 metabolism	C00847	3.17063492063	0.29852129812
Ketone body metabolism	C00003	3.17063492063	0.29852129812
Lactose synthesis	C00031	2.85357142857	0.322796814056
Phosphatidylinositol phosphate metabolism	C00055	2.85357142857	0.322796814056
Aspartate metabolism	C00327	2.59415584416	0.346204313928
Pyrimidine metabolism	C00055,C00881	1.67857142857	0.359119624111
Nicotinate and nicotinamide metabolism	C00003	2.37797619048	0.368775831662
2-oxobutanoate degradation	C00003	2.37797619048	0.368775831662
Lysine degradation	C00956	2.37797619048	0.368775831662
Glutaric aciduria type iii	C00956	2.19505494505	0.390542182294
Ethanol degradation	C00003	2.03826530612	0.411533009744
Selenoamino acid metabolism	C00041	2.03826530612	0.411533009744
Carnitine synthesis	C00003	1.78348214286	0.451301088409
Glutamate metabolism	C00003	1.67857142857	0.470132175317
Ammonia recycling	C00003	1.67857142857	0.470132175317
Insulin signalling	C00031	1.58531746032	0.488295493183
Phospholipid biosynthesis	C00093	1.58531746032	0.488295493183
Hypoacetylaspartia	C00041	1.50187969925	0.505815482201
Citric acid cycle	C00003	1.29707792208	0.554746257628
Histidine metabolism	C00003	1.24068322981	0.569919416887
Galactose metabolism	C00031	1.18898809524	0.584558309974
Tryptophan metabolism	C01717	0.864718614719	0.695242469572
Arachidonic acid metabolism	C00219	0.792658730159	0.724944604087
Purine metabolism	C00294	0.648538961039	0.790383077349

Pathway	hits	oddsratio	pvalue
Transcription/translation	C00148,C00123,C00073,C00407,C00064,C00041,C00079,C00047,C00188,C00183,C00097	9.57407407407	1.20985112599e-06
Hartnup disorder	C00047,C00041,C00123,C00407,C00183	18.4953703704	0.000129710636765
Citrullinemia type i	C00041,C00047,C00064,C00327	29.5925925926	0.00025468574764
Pantothenate and coa biosynthesis	C00010,C01134,C00882,C00097	9.86419753086	0.00285129833583
Hypermethioninemia	C00073,C00097	inf	0.00421819576263
Ornithine transcarbamylase deficiency (otc deficiency)	C00041,C00327,C00064	11.0972222222	0.00799335338733
Glutaric aciduria type iii	C00489,C00408,C00047,C00956	5.91851851852	0.0109034699484
Nucleotide sugars metabolism	C00029,C00052,C00668	7.39814814815	0.0173235896325
Galactose metabolism	C01835,C00159,C00029,C00052,C00668	3.69907407407	0.0216325875561
Phenylacetate metabolism	C00010,C00064	9.86419753086	0.0368441835589
Lysine degradation	C00408,C00047,C00956	4.43888888889	0.0482392871813
Glycine n-methyltransferase deficiency	C00073	inf	0.0644028103045
Lactic acidemia	C00041	inf	0.0644028103045
Glutaric aciduria type i	C00489	inf	0.0644028103045
Pyruvate dehydrogenase complex deficiency	C00186	inf	0.0644028103045
Gamma-glutamyltransferase deficiency	C00051	inf	0.0644028103045
Methionine adenosyltransferase deficiency	C00073	inf	0.0644028103045
Pyruvaldehyde degradation	C03451,C00051	5.91851851852	0.0708095637404
Glycine, serine and threonine metabolism	C00065,C00597,C00188,C00097	2.69023569024	0.0857652596156
Glycerol phosphate shuttle	C00093,C00016	4.93209876543	0.0903621123752
Tyrosinemia type 3 (tyro3)	C00079	14.7962962963	0.124587424846
Tyrosinemia type 2 (or richner-hanhart syndrome)	C00079	14.7962962963	0.124587424846
Methylenetetrahydrofolate reductase deficiency (mthfrd)	C00073	14.7962962963	0.124587424846
Pyruvate decarboxylase e1 component deficiency (pdhe1 deficiency)	C00186	14.7962962963	0.124587424846
Molybdenium cofactor deficiency	C00385	14.7962962963	0.124587424846
Lysinuric protein intolerance	C00047	14.7962962963	0.124587424846
Iminoglycinuria	C00148	14.7962962963	0.124587424846
Saccharopinuria/hyperlysinemia ii	C00047	14.7962962963	0.124587424846
Prolinemia type ii	C00148	14.7962962963	0.124587424846
Xanthine dehydrogenase deficiency (xanthinuria)	C00385	14.7962962963	0.124587424846
Glycogen storage disease type 1a (gsd1a) or von gierke ddisease	C00186	14.7962962963	0.124587424846
Ump synthase deiciency (orotic aciduria)	C00106	14.7962962963	0.124587424846
Glutathione metabolism	C00051,C00097	3.69907407407	0.133156327116
Urea cycle	C00041,C00327,C00064	2.61111111111	0.136554606584
Lactose synthesis	C00029,C00052	3.28806584362	0.155911387257
Pyruvate carboxylase deficiency	C00041	7.39814814815	0.180834728157
Hyperprolinemia type i	C00148	7.39814814815	0.180834728157
Glutathione synthetase deficiency	C00051	7.39814814815	0.180834728157
Cystathionine beta-synthase deficiency	C00073	7.39814814815	0.180834728157
Methionine metabolism	C00073,C00065,C00097	2.11375661376	0.200499425568
Beta-alanine metabolism	C00010,C00106	2.69023569024	0.203120404602
Oxidation of branched chain fatty acids	C00010,C02571	2.46604938272	0.22723684157
Beta oxidation of very long chain fatty acids	C00010,C02571	2.46604938272	0.22723684157
Starch and sucrose metabolism	C00029,C00668	2.46604938272	0.22723684157
Hyperprolinemia type ii	C00148	4.93209876543	0.233406595078
Argininosuccinic aciduria	C00327	4.93209876543	0.233406595078
Biotin metabolism	C00047	4.93209876543	0.233406595078
Biotinidase deficiency	C00047	4.93209876543	0.233406595078
Gluconeogenesis	C00186,C00597,C00668	1.84953703704	0.251961055963
Phenylketonuria	C00079	3.69907407407	0.282547197957
Mngie (mitochondrial neurogastrointestinal encephalopathy)	C00106	3.69907407407	0.282547197957
Glutamate metabolism	C00064,C00051	1.84953703704	0.32405812062
Ammonia recycling	C00065,C00064	1.84953703704	0.32405812062
Insulin signalling	C00010,C00029	1.74074074074	0.347853812982
Glycerolipid metabolism	C00093,C00597	1.74074074074	0.347853812982
Hypoacetylaspartia	C02571,C00041	1.64403292181	0.371331502581
Pyruvate metabolism	C00186,C03451	1.64403292181	0.371331502581
Leigh syndrome	C00186,C03451	1.64403292181	0.371331502581
Homocysteine degradation	C00065	2.46604938272	0.371429999001
Taurine and hypotaurine metabolism	C00097	2.46604938272	0.371429999001
Alanine metabolism	C00041	2.46604938272	0.371429999001
Glycolysis	C00597,C00668	1.55750487329	0.39443311935
Pyrimidine metabolism	C00106,C00064,C00299	1.34511784512	0.410169486712
Valine, leucine and isoleucine degradation	C00123,C00407,C00183	1.34511784512	0.410169486712
Cysteine metabolism	C00097	2.11375661376	0.411582554234
Citric acid cycle	C00010,C00016	1.40917107584	0.439320256945
Riboflavin metabolism	C00016	1.84953703704	0.449126590797
Spermidine and spermine biosynthesis	C00073	1.84953703704	0.449126590797
Butyrate metabolism	C00010	1.84953703704	0.449126590797
Prolidase deficiency(pd)	C00148,C00327	1.28663446055	0.48221541721
Betaine metabolism	C00073	1.64403292181	0.484234397873
Vitamin b6 metabolism	C00847	1.64403292181	0.484234397873
Ketone body metabolism	C00010	1.64403292181	0.484234397873
Arginine and proline metabolism	C00148,C00327	1.23302469136	0.502851310671
Aspartate metabolism	C00327	1.34511784512	0.54777344062
Glucose-alanine cycle	C00041	1.34511784512	0.54777344062
Purine metabolism	C00385,C00294,C00064	1.05687830688	0.555417142104
Phenylalanine and tyrosine metabolism	C00079	1.23302469136	0.576494526956
2-oxobutanoate degradation	C00010	1.23302469136	0.576494526956
Ethanol degradation	C00010	1.05687830688	0.62849318979
Selenoamino acid metabolism	C00041	1.05687830688	0.62849318979
Sphingolipid metabolism	C00065	1.05687830688	0.62849318979
Amino sugar metabolism	C00329	1.05687830688	0.62849318979
Mitochondrial electron transport chain	C00093	1.05687830688	0.62849318979
Transfer of acetyl groups into mitochondria	C00010	0.986419753086	0.652006279045
Carnitine synthesis	C00047	0.924768518519	0.674005882093
Pentose phosphate pathway	C00668	0.87037037037	0.694591044534
Fructose and mannose degradation	C00159	0.87037037037	0.694591044534
Propanoate metabolism	C00183	0.87037037037	0.694591044534
Phospholipid biosynthesis	C00093	0.822016460905	0.713854224064
Inositol metabolism	C00668	0.822016460905	0.713854224064
Inositol phosphate metabolism	C00668	0.778752436647	0.73188173572
Fatty acid metabolism	C00010	0.528439153439	0.850213753294
Fatty acid biosynthesis	C06424	0.477299880526	0.876468231491
Tryptophan metabolism	C01717	0.448372615039	0.891320991583
Bile acid biosynthesis	C00010	0.30825617284	0.958026115536

Pathway	hits	oddsratio	pvalue
Betaine metabolism	C01026,C00114,C00021,C00719,C00019	36.3181818182	5.57275837768e-06
Methionine metabolism	C00114,C00021,C01026,C00019,C00170,C00719	12.1060606061	6.76787938985e-05
S-adenosylhomocysteine (sah) hydrolase deficiency	C00019,C00021	inf	0.000815957286409
Carnitine synthesis	C00019,C00318,C00021	7.78246753247	0.0121118113126
Spermidine and spermine biosynthesis	C00019,C00170	10.3766233766	0.025497870937
Dimethylglycine dehydrogenase deficiency	C01026	inf	0.0279805352798
Glutathione metabolism	C00025,C00127	9.07954545455	0.0312433388118
Dihydropyrimidine dehydrogenase deficiency (dhpd)	C01026	36.3181818182	0.0551451132732
Oxidation of branched chain fatty acids	C03017,C00318	6.05303030303	0.0583808020033
Glutamate metabolism	C00025,C00127	4.53977272727	0.0908024957827
Thiamine metabolism	C00378	12.1060606061	0.107124641155
Obesity / metabolic syndrome	C00249	12.1060606061	0.107124641155
2-hydroxyglutric aciduria (d and l form)	C00025,C01089	3.82296650718	0.117647230272
Glycine, serine and threonine metabolism	C01026,C00719	3.02651515152	0.165621843713
Alanine metabolism	C00025	6.05303030303	0.179568326378
Cysteine metabolism	C00025	5.18831168831	0.202330604416
Malate-aspartate shuttle	C00025	5.18831168831	0.202330604416
Hartnup disorder	C00025	4.53977272727	0.224434696101
Fatty acid biosynthesis	C00249,C01089	2.42121212121	0.226133552375
Ketone body metabolism	C01089	4.03535353535	0.245900402466
Glucose-alanine cycle	C00025	3.30165289256	0.286992789518
Beta oxidation of very long chain fatty acids	C00318	2.79370629371	0.325754154521
Sphingolipid metabolism	C00550	2.59415584416	0.344303980413
Catecholamine biosynthesis	C00019	2.59415584416	0.344303980413
Purine metabolism	C00387,C00147	1.68921775899	0.357654810596
Ammonia recycling	C00025	2.13636363636	0.396825070373
Insulin signalling	C00249	2.01767676768	0.413340574398
Phospholipid biosynthesis	C00114	2.01767676768	0.413340574398
Glycerolipid metabolism	C00249	2.01767676768	0.413340574398
Urea cycle	C00025	1.91148325359	0.429384767964
Histidine metabolism	C00025	1.5790513834	0.489121921595
Prolidase deficiency(pd)	C00025	1.51325757576	0.50301104193
Fatty acid elongation in mitochondria	C00249	1.45272727273	0.516506609858
Arginine and proline metabolism	C00025	1.45272727273	0.516506609858
Transcription/translation	C00025	1.34511784512	0.542363142665
Fatty acid metabolism	C00249	1.29707792208	0.554746257628
Bile acid biosynthesis	C05465	0.756628787879	0.741014446155

Pathway	hits	oddsratio	pvalue
Ornithine transcarbamylase deficiency (otc deficiency)	C00295,C00077	11.837037037	0.022061595846
Non ketotic hyperglycinemia	C00037	inf	0.0338573155986
Renal glucosuria	C00031	inf	0.0338573155986
Ornithine aminotransferase deficiency (oat deficiency)	C00077	inf	0.0338573155986
Pyrimidine metabolism	C00055,C00295,C00881,C00239	3.69907407407	0.0359764767383
Glucose-alanine cycle	C00003,C00031	5.91851851852	0.0615781728034
Iminoglycinuria	C00037	29.5925925926	0.0665288073416
Glycogen storage disease type 1a (gsd1a) or von gierke ddisease	C00031	29.5925925926	0.0665288073416
Ump synthase deiciency (orotic aciduria)	C00295	29.5925925926	0.0665288073416
Transfer of acetyl groups into mitochondria	C00003,C00031	4.22751322751	0.102000796007
Carnitine synthesis	C00037,C00003	3.94567901235	0.112967220028
Ammonia recycling	C00037,C00003	3.69907407407	0.124204881137
Hyperprolinemia type ii	C00077	9.86419753086	0.128484367715
Gliclazide pathway	C00031	9.86419753086	0.128484367715
Glibenclamide pathway	C00031	9.86419753086	0.128484367715
Urea cycle	C00086,C00077	3.28806584362	0.147365404603
Glycolysis	C00003,C00031	3.11500974659	0.159229000552
Methionine metabolism	C00037,C00440	2.69023569024	0.195635923697
Prolidase deficiency(pd)	C00086,C00077	2.5732689211	0.207965262296
Galactose metabolism	C00794,C00031	2.5732689211	0.207965262296
Taurine and hypotaurine metabolism	C00519	4.93209876543	0.213546038617
Alanine metabolism	C00037	4.93209876543	0.213546038617
Arginine and proline metabolism	C00086,C00077	2.46604938272	0.220356102878
Gluconeogenesis	C00003,C00031	2.36740740741	0.232789359936
One carbon pool by folate	C00440	4.22751322751	0.239949768736
Lactose degradation	C00031	4.22751322751	0.239949768736
Glycerol phosphate shuttle	C00003	4.22751322751	0.239949768736
Lactose intolerance	C00031	4.22751322751	0.239949768736
Malate-aspartate shuttle	C00003	4.22751322751	0.239949768736
Alpha linolenic acid and linoleic acid metabolism	C00219	3.69907407407	0.265436483078
Riboflavin metabolism	C00255	3.69907407407	0.265436483078
Spermidine and spermine biosynthesis	C00077	3.69907407407	0.265436483078
Glutathione metabolism	C00037	3.28806584362	0.290039088908
Betaine metabolism	C00440	3.28806584362	0.290039088908
Ketone body metabolism	C00003	3.28806584362	0.290039088908
Lactose synthesis	C00031	2.95925925926	0.313789274702
Phosphatidylinositol phosphate metabolism	C00055	2.95925925926	0.313789274702
Nicotinate and nicotinamide metabolism	C00003	2.46604938272	0.358853323575
2-oxobutanoate degradation	C00003	2.46604938272	0.358853323575
Ethanol degradation	C00003	2.11375661376	0.400859485133
Mitochondrial electron transport chain	C00003	2.11375661376	0.400859485133
Glutamate metabolism	C00003	1.74074074074	0.458599381067
Fructose and mannose degradation	C00794	1.74074074074	0.458599381067
Insulin signalling	C00031	1.64403292181	0.476539283232
Glycerolipid metabolism	C00003	1.64403292181	0.476539283232
Citric acid cycle	C00003	1.34511784512	0.542363142666
Histidine metabolism	C00003	1.28663446055	0.557438239142
Glycine, serine and threonine metabolism	C00037	1.1837037037	0.58606535359
Transcription/translation	C00055	1.09602194787	0.612779026502
Arachidonic acid metabolism	C00219	0.822016460905	0.712638619023
Bile acid biosynthesis	C00037	0.616512345679	0.805982890133

Pathway	hits	oddsratio	pvalue
Lysinuric protein intolerance	C00062,C00047	inf	0.000167864609562
Hartnup disorder	C00062,C00047,C00183	44.3888888889	0.000194116445387
Transcription/translation	C00062,C00047,C00064,C00183	14.7962962963	0.000587195979623
Urea cycle	C00062,C00077,C00064	15.6666666667	0.00231264284813
Citrullinemia type i	C00047,C00064	44.3888888889	0.00242038955469
Ornithine transcarbamylase deficiency (otc deficiency)	C00077,C00064	35.5111111111	0.00335540793531
Pyrimidine metabolism	C00214,C00475,C00064	8.07070707071	0.0120384321822
Ornithine aminotransferase deficiency (oat deficiency)	C00077	inf	0.0123609394314
Saccharopinuria/hyperlysinemia ii	C00047	88.7777777778	0.0245540142533
Argininemia	C00062	44.3888888889	0.0365817082822
Prolidase deficiency(pd)	C00062,C00077	7.71980676329	0.0403078977422
Arginine and proline metabolism	C00062,C00077	7.39814814815	0.0432570611864
Hyperprolinemia type ii	C00077	29.5925925926	0.0484464655694
Argininosuccinic aciduria	C00062	29.5925925926	0.0484464655694
Biotin metabolism	C00047	29.5925925926	0.0484464655694
Biotinidase deficiency	C00047	29.5925925926	0.0484464655694
Phenylacetate metabolism	C00064	22.1944444444	0.0601506910852
Mngie (mitochondrial neurogastrointestinal encephalopathy)	C00214	22.1944444444	0.0601506910852
Spermidine and spermine biosynthesis	C00077	11.0972222222	0.10540904431
Lysine degradation	C00047	7.39814814815	0.148281572332
Glutaric aciduria type iii	C00047	6.82905982906	0.158643110382
Carnitine synthesis	C00047	5.54861111111	0.188904822666
Glutamate metabolism	C00064	5.22222222222	0.198724376871
Ammonia recycling	C00064	5.22222222222	0.198724376871
Propanoate metabolism	C00183	5.22222222222	0.198724376871
Histidine metabolism	C01152	3.85990338164	0.254964099552
Valine, leucine and isoleucine degradation	C00183	2.53650793651	0.354866673512
Purine metabolism	C00064	2.01767676768	0.420120869288

Pathway	hits	oddsratio	pvalue
Dihydropyrimidine dehydrogenase deficiency (dhpd)	C01026,C00213	inf	0.000236890538349
Glycine, serine and threonine metabolism	C01026,C00065,C00213	9.4743083004	0.00775260287784
Histidinemia	C00135	inf	0.0147965474723
Sarcosinemia	C00213	inf	0.0147965474723
Dimethylglycine dehydrogenase deficiency	C01026	inf	0.0147965474723
Ammonia recycling	C00135,C00065	9.07954545455	0.0302290660314
Methionine metabolism	C01026,C00065	6.60330578512	0.0510335687828
Homocysteine degradation	C00065	12.1060606061	0.0987413061366
Hartnup disorder	C00135	9.07954545455	0.124974240526
Pantothenate and coa biosynthesis	C00864	8.07070707071	0.137779495542
Betaine metabolism	C01026	8.07070707071	0.137779495542
Beta-alanine metabolism	C00864	6.05303030303	0.174992433968
Sphingolipid metabolism	C00065	5.18831168831	0.198832458426
Histidine metabolism	C00135	3.1581027668	0.297251886072
Transcription/translation	C00135	2.69023569024	0.336717556694

Pathway	hits	oddsratio	pvalue
Spermidine and spermine biosynthesis	C00073,C00170,C00315	23.5	0.000935037431047
Methionine metabolism	C00114,C00170,C00315,C00073	9.4	0.00222222920526
Betaine metabolism	C00114,C00073	11.75	0.020222381619
Glycine n-methyltransferase deficiency	C00073	inf	0.0220318237454
Methionine adenosyltransferase deficiency	C00073	inf	0.0220318237454
Hypermethioninemia	C00073	47.0	0.0435519058635
Methylenetetrahydrofolate reductase deficiency (mthfrd)	C00073	47.0	0.0435519058635
Ump synthase deiciency (orotic aciduria)	C00295	47.0	0.0435519058635
Mitochondrial electron transport chain	C00122,C00003	7.23076923077	0.0435741224338
Pyrimidine metabolism	C00055,C00295,C00299	4.27272727273	0.0481527039273
Carnitine synthesis	C00318,C00003	6.26666666667	0.0546881612883
Cystathionine beta-synthase deficiency	C00073	23.5	0.0645727430974
Citric acid cycle	C00122,C00003	4.47619047619	0.0926662142639
Transcription/translation	C00055,C00073	3.61538461538	0.128253240701
Ornithine transcarbamylase deficiency (otc deficiency)	C00295	7.83333333333	0.143902555123
Glycerol phosphate shuttle	C00003	6.71428571429	0.1626037129
Malate-aspartate shuttle	C00003	6.71428571429	0.1626037129
Nucleotide sugars metabolism	C00052	5.875	0.180874177346
Ketone body metabolism	C00003	5.22222222222	0.198724376871
Lactose synthesis	C00052	4.7	0.216164475077
Phosphatidylinositol phosphate metabolism	C00055	4.7	0.216164475077
Aspartate metabolism	C00122	4.27272727273	0.233204377793
Glucose-alanine cycle	C00003	4.27272727273	0.233204377793
Nicotinate and nicotinamide metabolism	C00003	3.91666666667	0.249853739916
Phenylalanine and tyrosine metabolism	C00122	3.91666666667	0.249853739916
2-oxobutanoate degradation	C00003	3.91666666667	0.249853739916
Oxidation of branched chain fatty acids	C00318	3.61538461538	0.266121972061
Beta oxidation of very long chain fatty acids	C00318	3.61538461538	0.266121972061
Ethanol degradation	C00003	3.35714285714	0.282018247035
Transfer of acetyl groups into mitochondria	C00003	3.13333333333	0.297551506114
Glutamate metabolism	C00003	2.76470588235	0.327563620594
Ammonia recycling	C00003	2.76470588235	0.327563620594
Phospholipid biosynthesis	C00114	2.61111111111	0.342059255119
Glycerolipid metabolism	C00003	2.61111111111	0.342059255119
Urea cycle	C00122	2.47368421053	0.356225443406
Hypoacetylaspartia	C00122	2.47368421053	0.356225443406
Glycolysis	C00003	2.35	0.370070057526
Histidine metabolism	C00003	2.04347826087	0.409750247436
Prolidase deficiency(pd)	C00122	1.95833333333	0.422383416933
Galactose metabolism	C00052	1.95833333333	0.422383416933
Arginine and proline metabolism	C00122	1.88	0.434731514908
Gluconeogenesis	C00003	1.80769230769	0.446801304625
Tyrosine metabolism	C00122	1.27027027027	0.562974915971
Purine metabolism	C00147	1.06818181818	0.623252833475

Pathway	hits	oddsratio	pvalue
Hartnup disorder	C00135,C00062,C00047,C00183	33.6421052632	5.25297993792e-05
Lysinuric protein intolerance	C00062,C00047	inf	0.000625390869293
Transcription/translation	C00135,C00062,C00047,C00183,C00064	9.14187643021	0.00075435668503
Citrullinemia type i	C00047,C00064	21.0263157895	0.00873130407147
Ornithine transcarbamylase deficiency (otc deficiency)	C00077,C00064	16.8210526316	0.0120082253803
Urea cycle	C00062,C00077,C00064	7.42105263158	0.0134142942459
Histidinemia	C00135	inf	0.02442002442
Sarcosinemia	C00213	inf	0.02442002442
Ornithine aminotransferase deficiency (oat deficiency)	C00077	inf	0.02442002442
Saccharopinuria/hyperlysinemia ii	C00047	42.0526315789	0.0482146579708
Dihydropyrimidine dehydrogenase deficiency (dhpd)	C00213	42.0526315789	0.0482146579708
Pyrimidine metabolism	C00214,C00475,C00064	3.82296650718	0.0610404622867
Argininemia	C00062	21.0263157895	0.0714006589946
Ammonia recycling	C00135,C00064	5.25657894737	0.0722072566735
Hyperprolinemia type ii	C00077	14.0175438596	0.0939943169267
Argininosuccinic aciduria	C00062	14.0175438596	0.0939943169267
Biotin metabolism	C00047	14.0175438596	0.0939943169267
Biotinidase deficiency	C00047	14.0175438596	0.0939943169267
Phenylacetate metabolism	C00064	10.5131578947	0.116011465968
Mngie (mitochondrial neurogastrointestinal encephalopathy)	C00214	10.5131578947	0.116011465968
Histidine metabolism	C00135,C01152	3.82296650718	0.117647230272
Prolidase deficiency(pd)	C00062,C00077	3.65675057208	0.125750573353
Glycine, serine and threonine metabolism	C00213,C00597	3.50438596491	0.133971530122
Arginine and proline metabolism	C00062,C00077	3.50438596491	0.133971530122
Nucleotide sugars metabolism	C00052	5.25657894737	0.198616455471
Spermidine and spermine biosynthesis	C00077	5.25657894737	0.198616455471
Pantothenate and coa biosynthesis	C00864	4.67251461988	0.217973545919
Betaine metabolism	C00114	4.67251461988	0.217973545919
Lactose synthesis	C00052	4.20526315789	0.236840287874
Beta-alanine metabolism	C00864	3.50438596491	0.273154355339
Lysine degradation	C00047	3.50438596491	0.273154355339
Glutaric aciduria type iii	C00047	3.23481781377	0.290626606412
Carnitine synthesis	C00047	2.62828947368	0.340446655254
Pentose phosphate pathway	C00345	2.47368421053	0.356225443406
Glutamate metabolism	C00064	2.47368421053	0.356225443406
Propanoate metabolism	C00183	2.47368421053	0.356225443406
Phospholipid biosynthesis	C00114	2.33625730994	0.371608347984
Glycerolipid metabolism	C00597	2.33625730994	0.371608347984
Glycolysis	C00597	2.10263157895	0.401227794006
Methionine metabolism	C00114	1.82837528604	0.44293857395
Galactose metabolism	C00052	1.75219298246	0.456154740642
Gluconeogenesis	C00597	1.61740890688	0.481609120683
Valine, leucine and isoleucine degradation	C00183	1.2015037594	0.581602604636
Purine metabolism	C00064	0.955741626794	0.66154004421

Pathway	hits	oddsratio	pvalue
Methionine metabolism	C01026,C00134,C00065	8.15306122449	0.0108296013154
Dimethylglycine dehydrogenase deficiency	C01026	inf	0.0184275184275
Dihydropyrimidine dehydrogenase deficiency (dhpd)	C01026	57.0714285714	0.0364932696221
Glycine, serine and threonine metabolism	C01026,C00065	4.75595238095	0.0849149729592
Homocysteine degradation	C00065	9.5119047619	0.121653574302
Spermidine and spermine biosynthesis	C00134	7.13392857143	0.153436693986
Hartnup disorder	C00407	7.13392857143	0.153436693986
Betaine metabolism	C01026	6.34126984127	0.168866158858
Lysine degradation	C00956	4.75595238095	0.213381505792
Oxidation of branched chain fatty acids	C02571	4.39010989011	0.227649072192
Beta oxidation of very long chain fatty acids	C02571	4.39010989011	0.227649072192
Glutaric aciduria type iii	C00956	4.39010989011	0.227649072192
Sphingolipid metabolism	C00065	4.07653061224	0.241640936826
Carnitine synthesis	C01181	3.56696428571	0.268820053046
Ammonia recycling	C00065	3.35714285714	0.282018247035
Hypoacetylaspartia	C02571	3.0037593985	0.307658380568
Pyruvate metabolism	C00074	3.0037593985	0.307658380568
Leigh syndrome	C00074	3.0037593985	0.307658380568
Glycolysis	C00074	2.85357142857	0.320110567968
Gluconeogenesis	C00074	2.19505494505	0.389979209439
Transcription/translation	C00407	2.11375661376	0.400859485133
Valine, leucine and isoleucine degradation	C00407	1.6306122449	0.480797921841

Pathway	hits	oddsratio	pvalue
Spermidine and spermine biosynthesis	C00073,C00170,C00315	13.775862069	0.00365245956438
Glycine n-methyltransferase deficiency	C00073	inf	0.0361881785284
Pyruvate dehydrogenase complex deficiency	C00186	inf	0.0361881785284
Methionine adenosyltransferase deficiency	C00073	inf	0.0361881785284
Pyrimidine metabolism	C00055,C00295,C02642,C00299	3.44396551724	0.0437562109577
Methionine metabolism	C00073,C00170,C00315	3.93596059113	0.0569621745881
Prolidase deficiency(pd)	C00086,C00122,C00300	3.75705329154	0.0629259129355
Arginine and proline metabolism	C00086,C00122,C00300	3.59370314843	0.0691577492851
Hypermethioninemia	C00073	27.5517241379	0.0710247503888
Arginine: glycine amidinotransferase deficiency (agat deficiency)	C00300	27.5517241379	0.0710247503888
Methylenetetrahydrofolate reductase deficiency (mthfrd)	C00073	27.5517241379	0.0710247503888
Pyruvate decarboxylase e1 component deficiency (pdhe1 deficiency)	C00186	27.5517241379	0.0710247503888
Guanidinoacetate methyltransferase deficiency (gamt deficiency)	C00300	27.5517241379	0.0710247503888
Dihydropyrimidinase deficiency	C02642	27.5517241379	0.0710247503888
Beta ureidopropionase deficiency	C02642	27.5517241379	0.0710247503888
Glycogen storage disease type 1a (gsd1a) or von gierke ddisease	C00186	27.5517241379	0.0710247503888
Ump synthase deiciency (orotic aciduria)	C00295	27.5517241379	0.0710247503888
Gluconeogenesis	C00186,C00003,C00668	3.44396551724	0.0756483343955
Transcription/translation	C00055,C00123,C00073	3.30620689655	0.0823879274674
Oxidation of branched chain fatty acids	C03017,C00318	4.59195402299	0.0906803499602
Mitochondrial electron transport chain	C00122,C00003	4.23872679045	0.102079941173
Cystathionine beta-synthase deficiency	C00073	13.775862069	0.10456176301
Carnitine synthesis	C00318,C00003	3.67356321839	0.125890186364
Urea cycle	C00086,C00122	3.06130268199	0.163537362345
Pyruvate metabolism	C00227,C00186	3.06130268199	0.163537362345
Leigh syndrome	C00227,C00186	3.06130268199	0.163537362345
Glycolysis	C00003,C00668	2.9001814882	0.176460726147
Citric acid cycle	C00122,C00003	2.62397372742	0.202685499884
Ornithine transcarbamylase deficiency (otc deficiency)	C00295	4.59195402299	0.226684661209
Glycerol phosphate shuttle	C00003	3.93596059113	0.254435211645
Malate-aspartate shuttle	C00003	3.93596059113	0.254435211645
Nucleotide sugars metabolism	C00668	3.44396551724	0.281157963915
Hartnup disorder	C00123	3.44396551724	0.281157963915
Pantothenate and coa biosynthesis	C01134	3.06130268199	0.306892165685
Betaine metabolism	C00073	3.06130268199	0.306892165685
Ketone body metabolism	C00003	3.06130268199	0.306892165685
Phosphatidylinositol phosphate metabolism	C00055	2.75517241379	0.331675520904
Aspartate metabolism	C00122	2.50470219436	0.355544252301
Glucose-alanine cycle	C00003	2.50470219436	0.355544252301
Nicotinate and nicotinamide metabolism	C00003	2.29597701149	0.378533161256
Beta-alanine metabolism	C02642	2.29597701149	0.378533161256
Phenylalanine and tyrosine metabolism	C00122	2.29597701149	0.378533161256
2-oxobutanoate degradation	C00003	2.29597701149	0.378533161256
Beta oxidation of very long chain fatty acids	C00318	2.11936339523	0.400675685201
Starch and sucrose metabolism	C00668	2.11936339523	0.400675685201
Ethanol degradation	C00003	1.96798029557	0.422003952631
Sphingolipid metabolism	C00319	1.96798029557	0.422003952631
Transfer of acetyl groups into mitochondria	C00003	1.8367816092	0.442548835833
Pentose phosphate pathway	C00668	1.62068965517	0.48140595882
Glutamate metabolism	C00003	1.62068965517	0.48140595882
Ammonia recycling	C00003	1.62068965517	0.48140595882
Phospholipid biosynthesis	C00307	1.530651341	0.499774106678
Inositol metabolism	C00668	1.530651341	0.499774106678
Glycerolipid metabolism	C00003	1.530651341	0.499774106678
Inositol phosphate metabolism	C00668	1.4500907441	0.517470777432
Hypoacetylaspartia	C00122	1.4500907441	0.517470777432
Histidine metabolism	C00003	1.19790104948	0.58203436289
Galactose metabolism	C00668	1.14798850575	0.596734209447
Glycine, serine and threonine metabolism	C00300	1.10206896552	0.610900455017
Valine, leucine and isoleucine degradation	C00123	0.787192118227	0.727250457706
Tyrosine metabolism	C00122	0.744641192917	0.745830880811
Purine metabolism	C00147	0.626175548589	0.801188073362

Pathway	hits	oddsratio	pvalue
Hartnup disorder	C00135,C00062,C00047,C00183	18.2628571429	0.000418670906606
Lysinuric protein intolerance	C00062,C00047	inf	0.00190814543162
Spermidine and spermine biosynthesis	C00170,C00077,C00315	11.4142857143	0.00589063468426
Transcription/translation	C00135,C00062,C00047,C00183,C00064	4.96273291925	0.00744498993051
Citrullinemia type i	C00047,C00064	11.4142857143	0.0253338322036
Ornithine transcarbamylase deficiency (otc deficiency)	C00077,C00064	9.13142857143	0.0344144458674
Pyruvate dehydrogenase complex deficiency	C00186	inf	0.0431137724551
Histidinemia	C00135	inf	0.0431137724551
Sarcosinemia	C00213	inf	0.0431137724551
Ornithine aminotransferase deficiency (oat deficiency)	C00077	inf	0.0431137724551
Urea cycle	C00062,C00064,C00077	4.02857142857	0.0548886492502
Pyruvate metabolism	C00227,C00186,C00074	4.02857142857	0.0548886492502
Leigh syndrome	C00227,C00186,C00074	4.02857142857	0.0548886492502
Pyruvate decarboxylase e1 component deficiency (pdhe1 deficiency)	C00186	22.8285714286	0.0843193994786
Saccharopinuria/hyperlysinemia ii	C00047	22.8285714286	0.0843193994786
Dihydropyrimidine dehydrogenase deficiency (dhpd)	C00213	22.8285714286	0.0843193994786
Glycogen storage disease type 1a (gsd1a) or von gierke ddisease	C00186	22.8285714286	0.0843193994786
Methionine metabolism	C00114,C00170,C00315	3.2612244898	0.0853126353616
Glycine, serine and threonine metabolism	C00258,C00213,C00597	2.97763975155	0.102615384655
Gluconeogenesis	C00186,C00597,C00074	2.85357142857	0.11172856842
Argininemia	C00062	11.4142857143	0.123703511329
Hyperprolinemia type ii	C00077	7.60952380952	0.161348706546
Argininosuccinic aciduria	C00062	7.60952380952	0.161348706546
Biotin metabolism	C00047	7.60952380952	0.161348706546
Biotinidase deficiency	C00047	7.60952380952	0.161348706546
Glutamate metabolism	C00064,C00127	2.85357142857	0.181777473513
Ammonia recycling	C00135,C00064	2.85357142857	0.181777473513
Phenylacetate metabolism	C00064	5.70714285714	0.197333744168
Mngie (mitochondrial neurogastrointestinal encephalopathy)	C00214	5.70714285714	0.197333744168
Glycerolipid metabolism	C00258,C00597	2.68571428571	0.19748681766
Pyrimidine metabolism	C00214,C00475,C00064	2.07532467532	0.204347653454
Glycolysis	C00074,C00597	2.4030075188	0.229267955908
Histidine metabolism	C00135,C01152	2.07532467532	0.277264371331
Prolidase deficiency(pd)	C00062,C00077	1.9850931677	0.293217438621
Glycerol phosphate shuttle	C00016	3.2612244898	0.296061686834
Arginine and proline metabolism	C00062,C00077	1.90238095238	0.309100943119
Riboflavin metabolism	C00016	2.85357142857	0.32612310946
Nucleotide sugars metabolism	C00052	2.85357142857	0.32612310946
Pantothenate and coa biosynthesis	C00864	2.53650793651	0.354866673512
Glutathione metabolism	C00127	2.53650793651	0.354866673512
Betaine metabolism	C00114	2.53650793651	0.354866673512
Lactose synthesis	C00052	2.28285714286	0.382351643634
Beta-alanine metabolism	C00864	1.90238095238	0.43376932941
Lysine degradation	C00047	1.90238095238	0.43376932941
Glutaric aciduria type iii	C00047	1.75604395604	0.457807423915
Sphingolipid metabolism	C00319	1.6306122449	0.480797921841
Carnitine synthesis	C00047	1.42678571429	0.523821316553
Pentose phosphate pathway	C00345	1.34285714286	0.543941542615
Propanoate metabolism	C00183	1.34285714286	0.543941542615
Phospholipid biosynthesis	C00114	1.26825396825	0.563189027333
Purine metabolism	C00064,C00147	1.06179401993	0.576609879297
Citric acid cycle	C00016	1.03766233766	0.632202153382
Galactose metabolism	C00052	0.95119047619	0.662401597206
Valine, leucine and isoleucine degradation	C00183	0.652244897959	0.788495211503

Pathway	hits	oddsratio	pvalue
Methionine metabolism	C01026,C00134,C00065,C00719	8.41052631579	0.00313570934164
Betaine metabolism	C01026,C00719	10.5131578947	0.0244026414427
4-hydroxybutyric aciduria/succinic semialdehyde dehydrogenase deficiency	C00334	inf	0.02442002442
Dimethylglycine dehydrogenase deficiency	C01026	inf	0.02442002442
Glycine, serine and threonine metabolism	C01026,C00065,C00719	5.48512585812	0.0270990921249
Beta oxidation of very long chain fatty acids	C01585,C02571	7.00877192982	0.0460150913818
Dihydropyrimidine dehydrogenase deficiency (dhpd)	C01026	42.0526315789	0.0482146579708
Homocysteine degradation	C00065	7.00877192982	0.158377377176
Nucleotide sugars metabolism	C00029	5.25657894737	0.198616455471
Spermidine and spermine biosynthesis	C00134	5.25657894737	0.198616455471
Hartnup disorder	C00407	5.25657894737	0.198616455471
Lactose synthesis	C00029	4.20526315789	0.236840287874
Lysine degradation	C00956	3.50438596491	0.273154355339
Oxidation of branched chain fatty acids	C02571	3.23481781377	0.290626606412
Starch and sucrose metabolism	C00029	3.23481781377	0.290626606412
Glutaric aciduria type iii	C00956	3.23481781377	0.290626606412
Sphingolipid metabolism	C00065	3.0037593985	0.307658380568
Carnitine synthesis	C01181	2.62828947368	0.340446655254
Glutamate metabolism	C00334	2.47368421053	0.356225443406
Ammonia recycling	C00065	2.47368421053	0.356225443406
Insulin signalling	C00029	2.33625730994	0.371608347984
Hypoacetylaspartia	C02571	2.21329639889	0.386605762113
2-hydroxyglutric aciduria (d and l form)	C00334	2.10263157895	0.401227794006
Galactose metabolism	C00029	1.75219298246	0.456154740642
Transcription/translation	C00407	1.55750487329	0.493864224213
Fatty acid biosynthesis	C01585	1.35653650255	0.539923949044
Valine, leucine and isoleucine degradation	C00407	1.2015037594	0.581602604636

Pathway	hits	oddsratio	pvalue
Prolidase deficiency(pd)	C00086,C00122,C00300,C00327	4.75595238095	0.0177222728599
Arginine and proline metabolism	C00086,C00122,C00300,C00327	4.53977272727	0.0202424025148
Transcription/translation	C00055,C00078,C00123,C00073	4.16145833333	0.0259030366808
Ornithine transcarbamylase deficiency (otc deficiency)	C00295,C00327	9.9875	0.0295383180449
Glycine n-methyltransferase deficiency	C00073	inf	0.0396634615384
Glutaric aciduria type i	C00489	inf	0.0396634615384
Gamma-glutamyltransferase deficiency	C00051	inf	0.0396634615384
Methionine adenosyltransferase deficiency	C00073	inf	0.0396634615384
Urea cycle	C00086,C00122,C00327	4.40625	0.044941564204
Pyrimidine metabolism	C00055,C00295,C02642,C00299	3.12109375	0.0570075161487
Hypermethioninemia	C00073	24.96875	0.0777080062794
Arginine: glycine amidinotransferase deficiency (agat deficiency)	C00300	24.96875	0.0777080062794
Methylenetetrahydrofolate reductase deficiency (mthfrd)	C00073	24.96875	0.0777080062794
Guanidinoacetate methyltransferase deficiency (gamt deficiency)	C00300	24.96875	0.0777080062794
Dihydropyrimidinase deficiency	C02642	24.96875	0.0777080062794
Beta ureidopropionase deficiency	C02642	24.96875	0.0777080062794
Ump synthase deiciency (orotic aciduria)	C00295	24.96875	0.0777080062794
Aspartate metabolism	C00122,C00327	4.99375	0.0809198740366
Oxidation of branched chain fatty acids	C03017,C00318	4.16145833333	0.105702096161
Maple syrup urine disease	C00671	12.484375	0.114201574376
Glutathione synthetase deficiency	C00051	12.484375	0.114201574376
Cystathionine beta-synthase deficiency	C00073	12.484375	0.114201574376
Mitochondrial electron transport chain	C00122,C00003	3.84134615385	0.118735663928
Carnitine synthesis	C00318,C00003	3.32916666667	0.145813756735
Thiamine metabolism	C00378	8.32291666667	0.149209176826
Argininosuccinic aciduria	C00327	8.32291666667	0.149209176826
Glutamate metabolism	C00003,C00051	3.12109375	0.15976035294
Glycolysis	C00003,C00668	2.62828947368	0.202715562612
Citrullinemia type i	C00327	4.99375	0.215012654944
Citric acid cycle	C00122,C00003	2.37797619048	0.231914732567
Pyruvaldehyde degradation	C00051	4.16145833333	0.245925044427
Sulfate/sulfite metabolism	C00054	4.16145833333	0.245925044427
Glycerol phosphate shuttle	C00003	3.56696428571	0.275584726828
Malate-aspartate shuttle	C00003	3.56696428571	0.275584726828
Gluconeogenesis	C00003,C00668	1.9975	0.290579614455
Alpha linolenic acid and linoleic acid metabolism	C16300	3.12109375	0.304043898274
Nucleotide sugars metabolism	C00668	3.12109375	0.304043898274
Spermidine and spermine biosynthesis	C00073	3.12109375	0.304043898274
Hartnup disorder	C00123	3.12109375	0.304043898274
Pantothenate and coa biosynthesis	C01134	2.77430555556	0.331352520577
Glutathione metabolism	C00051	2.77430555556	0.331352520577
Betaine metabolism	C00073	2.77430555556	0.331352520577
Ketone body metabolism	C00003	2.77430555556	0.331352520577
Phosphatidylinositol phosphate metabolism	C00055	2.496875	0.357558419413
Glucose-alanine cycle	C00003	2.26988636364	0.382707378084
Nicotinate and nicotinamide metabolism	C00003	2.08072916667	0.406843227046
Beta-alanine metabolism	C02642	2.08072916667	0.406843227046
Phenylalanine and tyrosine metabolism	C00122	2.08072916667	0.406843227046
2-oxobutanoate degradation	C00003	2.08072916667	0.406843227046
Valine, leucine and isoleucine degradation	C00671,C00123	1.46875	0.417816783993
Beta oxidation of very long chain fatty acids	C00318	1.92067307692	0.430007929421
Starch and sucrose metabolism	C00668	1.92067307692	0.430007929421
Glutaric aciduria type iii	C00489	1.92067307692	0.430007929421
Ethanol degradation	C00003	1.78348214286	0.452241662671
Transfer of acetyl groups into mitochondria	C00003	1.66458333333	0.473582896593
Pentose phosphate pathway	C00668	1.46875	0.513733651063
Ammonia recycling	C00003	1.46875	0.513733651063
Phospholipid biosynthesis	C00307	1.38715277778	0.532612226962
Inositol metabolism	C00668	1.38715277778	0.532612226962
Glycerolipid metabolism	C00003	1.38715277778	0.532612226962
Inositol phosphate metabolism	C00668	1.31414473684	0.550736547187
Hypoacetylaspartia	C00122	1.31414473684	0.550736547187
Methionine metabolism	C00073	1.08559782609	0.616291687208
Histidine metabolism	C00003	1.08559782609	0.616291687208
Galactose metabolism	C00668	1.04036458333	0.631084180576
Glycine, serine and threonine metabolism	C00300	0.99875	0.645289807227
Tryptophan metabolism	C00078	0.756628787879	0.740480188154
Tyrosine metabolism	C00122	0.674831081081	0.77777248418
Purine metabolism	C00387	0.567471590909	0.830311469438

Pathway	hits	oddsratio	pvalue
Hartnup disorder	C00123,C00407	32.612244898	0.00375268648557
Transcription/translation	C00123,C00407	8.78021978022	0.0338344517828
Mngie (mitochondrial neurogastrointestinal encephalopathy)	C00526	28.5357142857	0.0484756518212
Valine, leucine and isoleucine degradation	C00123,C00407	6.71428571429	0.0529750750932
Adrenal hyperplasia type 3 or congenital adrenal hyperplasia due to 21-hydroxylase deficiency	C02140	16.306122449	0.0762894647166
Adrenal hyperplasia type 5 or congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency	C02140	16.306122449	0.0762894647166
Steroidogenesis	C02140	3.56696428571	0.275584726827
Pyrimidine metabolism	C00526	3.2612244898	0.296061686834

Pathway	hits	oddsratio	pvalue
Hartnup disorder	C00047,C00183	57.0714285714	0.00160253122133
Lysinuric protein intolerance	C00047	199.75	0.0123914588548
Saccharopinuria/hyperlysinemia ii	C00047	199.75	0.0123914588548
Transcription/translation	C00047,C00183	15.3653846154	0.0151121450978
Biotin metabolism	C00047	66.5833333333	0.0245991156033
Biotinidase deficiency	C00047	66.5833333333	0.0245991156033
Citrullinemia type i	C00047	39.95	0.036626143116
Lysine degradation	C00047	16.6458333333	0.0773426436284
Glutaric aciduria type iii	C00047	15.3653846154	0.0829892614764
Carnitine synthesis	C00047	12.484375	0.0996820211489
Propanoate metabolism	C00183	11.75	0.105165078268
Valine, leucine and isoleucine degradation	C00183	5.70714285714	0.197333744168

Pathway	hits	oddsratio	pvalue
Alpha linolenic acid and linoleic acid metabolism	C06427,C03242	11.4142857143	0.0216825744579
Glycine n-methyltransferase deficiency	C00073	inf	0.0256097560976
Methionine adenosyltransferase deficiency	C00073	inf	0.0256097560976
Hypermethioninemia	C00073	39.95	0.0505332580731
Methylenetetrahydrofolate reductase deficiency (mthfrd)	C00073	39.95	0.0505332580731
Cystathionine beta-synthase deficiency	C00073	19.975	0.0747897076845
Obesity / metabolic syndrome	C00249	13.3166666667	0.098397746735
Mngie (mitochondrial neurogastrointestinal encephalopathy)	C00214	9.9875	0.121375474063
Transcription/translation	C00073,C00078	3.07307692308	0.162206686864
Spermidine and spermine biosynthesis	C00073	4.99375	0.207327146172
Betaine metabolism	C00073	4.43888888889	0.227406916897
Fructose and mannose degradation	C00159	2.35	0.370070057527
Insulin signalling	C00249	2.21944444444	0.385855891406
Glycerolipid metabolism	C00249	2.21944444444	0.385855891406
Methionine metabolism	C00073	1.73695652174	0.45879797398
Galactose metabolism	C00159	1.66458333333	0.472263901169
Fatty acid elongation in mitochondria	C00249	1.598	0.485379236169
Fatty acid metabolism	C00249	1.42678571429	0.522715660286
Fatty acid biosynthesis	C00249	1.28870967742	0.557224106072
Tryptophan metabolism	C00078	1.21060606061	0.578769613385
Pyrimidine metabolism	C00214	1.14142857143	0.599219337072

Pathway	hits	oddsratio	pvalue
Hartnup disorder	C00123,C00062,C00407,C00183,C00047	49.9375	1.92499528384e-06
Transcription/translation	C00148,C00123,C00073,C00062,C00407,C00047,C00183	13.3166666667	1.11286697088e-05
Lysinuric protein intolerance	C00062,C00047	inf	0.000686254121981
Mngie (mitochondrial neurogastrointestinal encephalopathy)	C00214,C00526	26.6333333333	0.00648683742157
Glycine n-methyltransferase deficiency	C00073	inf	0.0256097560976
Glycerol kinase deficiency	C00116	inf	0.0256097560976
Methionine adenosyltransferase deficiency	C00073	inf	0.0256097560976
Hypermethioninemia	C00073	39.95	0.0505332580731
Methylenetetrahydrofolate reductase deficiency (mthfrd)	C00073	39.95	0.0505332580731
Iminoglycinuria	C00148	39.95	0.0505332580731
Saccharopinuria/hyperlysinemia ii	C00047	39.95	0.0505332580731
Prolinemia type ii	C00148	39.95	0.0505332580731
Valine, leucine and isoleucine degradation	C00123,C00407,C00183	3.63181818182	0.0680111118118
Hyperprolinemia type i	C00148	19.975	0.0747897076845
Argininemia	C00062	19.975	0.0747897076845
Cystathionine beta-synthase deficiency	C00073	19.975	0.0747897076845
Hyperprolinemia type ii	C00148	13.3166666667	0.098397746735
Argininosuccinic aciduria	C00062	13.3166666667	0.098397746735
Biotin metabolism	C00047	13.3166666667	0.098397746735
Biotinidase deficiency	C00047	13.3166666667	0.098397746735
Prolidase deficiency(pd)	C00148,C00062	3.47391304348	0.135615721476
Citrullinemia type i	C00047	7.99	0.143740461996
Arginine and proline metabolism	C00148,C00062	3.32916666667	0.144380526155
Adrenal hyperplasia type 3 or congenital adrenal hyperplasia due to 21-hydroxylase deficiency	C02140	5.70714285714	0.186699971538
Adrenal hyperplasia type 5 or congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency	C02140	5.70714285714	0.186699971538
Spermidine and spermine biosynthesis	C00073	4.99375	0.207327146172
Betaine metabolism	C00073	4.43888888889	0.227406916897
Pyrimidine metabolism	C00526,C00214	2.35	0.235921757727
Lysine degradation	C00047	3.32916666667	0.284511318536
Oxidation of branched chain fatty acids	C03017	3.07307692308	0.302548848321
Glutaric aciduria type iii	C00047	3.07307692308	0.302548848321
Carnitine synthesis	C00047	2.496875	0.353858625183
Propanoate metabolism	C00183	2.35	0.370070057527
Glycerolipid metabolism	C00116	2.21944444444	0.385855891406
Urea cycle	C00062	2.10263157895	0.401227794006
Methionine metabolism	C00073	1.73695652174	0.45879797398
Galactose metabolism	C00116	1.66458333333	0.472263901169
Steroidogenesis	C02140	1.2484375	0.568137596415
Purine metabolism	C00294	0.907954545455	0.679168166907

Pathway	hits	oddsratio	pvalue
Transcription/translation	C00041,C00013,C00020,C00082	16.6458333333	0.000418027400078
Lactic acidemia	C00041	inf	0.0111386138614
Tyrosinemia type 3 (tyro3)	C00082	99.875	0.0221395439915
Tyrosinemia type 2 (or richner-hanhart syndrome)	C00082	99.875	0.0221395439915
Urea cycle	C00041,C00020	11.0972222222	0.022272888215
Pyruvate carboxylase deficiency	C00041	49.9375	0.0330046601694
Tyrosinemia type i	C00082	49.9375	0.0330046601694
Citrullinemia type i	C00041	19.975	0.0648034104362
Homocysteine degradation	C00065	16.6458333333	0.0751434218687
Alanine metabolism	C00041	16.6458333333	0.0751434218687
Ornithine transcarbamylase deficiency (otc deficiency)	C00041	16.6458333333	0.0751434218687
Nebivolol pathway	C00082	12.484375	0.095444541091
Hartnup disorder	C00041	12.484375	0.095444541091
Glucose-alanine cycle	C00041	9.07954545455	0.124974240526
Phenylalanine and tyrosine metabolism	C00082	8.32291666667	0.134578181788
Ethanol degradation	C00020	7.13392857143	0.153436693985
Selenoamino acid metabolism	C00041	7.13392857143	0.153436693985
Sphingolipid metabolism	C00065	7.13392857143	0.153436693985
Catecholamine biosynthesis	C00082	7.13392857143	0.153436693985
Ammonia recycling	C00065	5.875	0.180874177346
Insulin signalling	C00020	5.54861111111	0.189799277108
Inositol metabolism	C04006	5.54861111111	0.189799277108
Inositol phosphate metabolism	C04006	5.25657894737	0.198616455471
Hypoacetylaspartia	C00041	5.25657894737	0.198616455471
Methionine metabolism	C00065	4.34239130435	0.232834320331
Histidine metabolism	C00020	4.34239130435	0.232834320331
Glycine, serine and threonine metabolism	C00065	3.995	0.24933203089
Tyrosine metabolism	C00082	2.69932432432	0.340409851356
Purine metabolism	C00020	2.26988636364	0.387825620672

Pathway	hits	oddsratio	pvalue
Alpha linolenic acid and linoleic acid metabolism	C06427,C06428,C01595,C03242,C16300	23.7797619048	4.46605092749e-05
Fatty acid biosynthesis	C00249,C06424,C06423,C01571,C02679	3.52292768959	0.0244642106575
Beta oxidation of very long chain fatty acids	C06423,C01571,C02679	5.18831168831	0.0329970527544
Ornithine aminotransferase deficiency (oat deficiency)	C00077	inf	0.0510688836104
Tyrosinemia type 3 (tyro3)	C00079	19.0238095238	0.0994722501641
Tyrosinemia type 2 (or richner-hanhart syndrome)	C00079	19.0238095238	0.0994722501641
Maple syrup urine disease	C00671	9.5119047619	0.145352218462
Hyperprolinemia type ii	C00077	6.34126984127	0.188843170658
Obesity / metabolic syndrome	C00249	6.34126984127	0.188843170658
Phenylketonuria	C00079	4.75595238095	0.230072182078
Homocysteine degradation	C00109	3.17063492063	0.306218559518
Ornithine transcarbamylase deficiency (otc deficiency)	C00077	3.17063492063	0.306218559518
Galactose metabolism	C00159,C00089	1.65424430642	0.366234167015
Riboflavin metabolism	C00255	2.37797619048	0.374676660832
Spermidine and spermine biosynthesis	C00077	2.37797619048	0.374676660832
Transcription/translation	C00078,C00079	1.46336996337	0.420102751151
Phenylalanine and tyrosine metabolism	C00079	1.58531746032	0.491613116555
2-oxobutanoate degradation	C00109	1.58531746032	0.491613116555
Starch and sucrose metabolism	C00089	1.46336996337	0.517181111862
Carnitine synthesis	C01181	1.18898809524	0.586271978476
Fructose and mannose degradation	C00159	1.11904761905	0.606982461509
Propanoate metabolism	C01013	1.11904761905	0.606982461509
Insulin signalling	C00249	1.05687830688	0.626633338434
Glycerolipid metabolism	C00249	1.05687830688	0.626633338434
Urea cycle	C00077	1.00125313283	0.645279989359
Methionine metabolism	C00109	0.827122153209	0.710831816983
Histidine metabolism	C01152	0.827122153209	0.710831816983
Prolidase deficiency(pd)	C00077	0.792658730159	0.725190052399
Fatty acid elongation in mitochondria	C00249	0.760952380952	0.738819611506
Glycine, serine and threonine metabolism	C00109	0.760952380952	0.738819611506
Arginine and proline metabolism	C00077	0.760952380952	0.738819611506
Fatty acid metabolism	C00249	0.679421768707	0.775704110479
Tryptophan metabolism	C00078	0.576479076479	0.825763052007
Valine, leucine and isoleucine degradation	C00671	0.543537414966	0.842439406622

Pathway	hits	oddsratio	pvalue
Hartnup disorder	C00123,C00062,C00407,C00183,C00047	33.2916666667	1.06406814557e-05
Transcription/translation	C00148,C00123,C00073,C00062,C00407,C00047,C00183	8.87777777778	9.56450241684e-05
Lysinuric protein intolerance	C00062,C00047	inf	0.00143824395053
Mngie (mitochondrial neurogastrointestinal encephalopathy)	C00214,C00526	17.7555555556	0.0132760599343
Glycine n-methyltransferase deficiency	C00073	inf	0.0373493975903
Glycerol kinase deficiency	C00116	inf	0.0373493975903
Methionine adenosyltransferase deficiency	C00073	inf	0.0373493975903
Prolidase deficiency(pd)	C00086,C00148,C00062	3.63181818182	0.0677036541369
Hypermethioninemia	C00073	26.6333333333	0.0732605512301
Methylenetetrahydrofolate reductase deficiency (mthfrd)	C00073	26.6333333333	0.0732605512301
Iminoglycinuria	C00148	26.6333333333	0.0732605512301
Saccharopinuria/hyperlysinemia ii	C00047	26.6333333333	0.0732605512301
Prolinemia type ii	C00148	26.6333333333	0.0732605512301
Arginine and proline metabolism	C00086,C00148,C00062	3.47391304348	0.0743502173734
Hyperprolinemia type i	C00148	13.3166666667	0.107790506653
Argininemia	C00062	13.3166666667	0.107790506653
Cystathionine beta-synthase deficiency	C00073	13.3166666667	0.107790506653
Hyperprolinemia type ii	C00148	8.87777777778	0.140993981195
Argininosuccinic aciduria	C00062	8.87777777778	0.140993981195
Biotin metabolism	C00047	8.87777777778	0.140993981195
Biotinidase deficiency	C00047	8.87777777778	0.140993981195
Propanoate metabolism	C01013,C00183	3.32916666667	0.145336382981
Valine, leucine and isoleucine degradation	C00123,C00407,C00183	2.42121212121	0.153668090433
Urea cycle	C00086,C00062	2.95925925926	0.171722159419
Citrullinemia type i	C00047	5.32666666667	0.203629297071
Adrenal hyperplasia type 3 or congenital adrenal hyperplasia due to 21-hydroxylase deficiency	C02140	3.80476190476	0.261561278917
Adrenal hyperplasia type 5 or congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency	C02140	3.80476190476	0.261561278917
Alpha linolenic acid and linoleic acid metabolism	C16300	3.32916666667	0.288878224446
Spermidine and spermine biosynthesis	C00073	3.32916666667	0.288878224446
Betaine metabolism	C00073	2.95925925926	0.315153284091
Lysine degradation	C00047	2.21944444444	0.388128254965
Pyrimidine metabolism	C00526,C00214	1.56666666667	0.388817354075
Oxidation of branched chain fatty acids	C03017	2.04871794872	0.410628876668
Beta oxidation of very long chain fatty acids	C01571	2.04871794872	0.410628876668
Glutaric aciduria type iii	C00047	2.04871794872	0.410628876668
Carnitine synthesis	C00047	1.66458333333	0.473144043947
Glycerolipid metabolism	C00116	1.47962962963	0.510981998155
Methionine metabolism	C00073	1.15797101449	0.593794240135
Histidine metabolism	C01152	1.15797101449	0.593794240135
Galactose metabolism	C00116	1.10972222222	0.608539414088
Fatty acid biosynthesis	C01571	0.859139784946	0.697437595493
Steroidogenesis	C02140	0.832291666667	0.708318610041
Tryptophan metabolism	C01717	0.807070707071	0.718796157074
Purine metabolism	C00294	0.605303030303	0.811424385373
Bile acid biosynthesis	C17337	0.554861111111	0.836720300522

Pathway	hits	oddsratio	pvalue
Transcription/translation	C00013,C00020,C00144,C00041,C00188,C00082	13.6193181818	3.98076118575e-05
Alanine metabolism	C00037,C00041	19.975	0.00891941579666
Glycine, serine and threonine metabolism	C00037,C00065,C00188	6.51358695652	0.0183077749643
Lactic acidemia	C00041	inf	0.0208333333333
Non ketotic hyperglycinemia	C00037	inf	0.0208333333333
Tyrosinemia type 3 (tyro3)	C00082	49.9375	0.0412076703387
Tyrosinemia type 2 (or richner-hanhart syndrome)	C00082	49.9375	0.0412076703387
Iminoglycinuria	C00037	49.9375	0.0412076703387
Ammonia recycling	C00037,C00065	6.2421875	0.0550043896018
Pyruvate carboxylase deficiency	C00041	24.96875	0.0611336722999
Tyrosinemia type i	C00082	24.96875	0.0611336722999
Urea cycle	C00041,C00020	5.54861111111	0.0663046782205
Methionine metabolism	C00037,C00065	4.53977272727	0.0908024957827
Citrullinemia type i	C00041	9.9875	0.118324415352
Homocysteine degradation	C00065	8.32291666667	0.136558581944
Ornithine transcarbamylase deficiency (otc deficiency)	C00041	8.32291666667	0.136558581944
Nebivolol pathway	C00082	6.2421875	0.17183970136
Hartnup disorder	C00041	6.2421875	0.17183970136
Glutathione metabolism	C00037	5.54861111111	0.188904822666
Glucose-alanine cycle	C00041	4.53977272727	0.221927971584
Phenylalanine and tyrosine metabolism	C00082	4.16145833333	0.23790288038
Lysine degradation	C00956	4.16145833333	0.23790288038
Purine metabolism	C00020,C00144	2.3226744186	0.241734219685
Glutaric aciduria type iii	C00956	3.84134615385	0.253530927465
Ethanol degradation	C00020	3.56696428571	0.268820053046
Selenoamino acid metabolism	C00041	3.56696428571	0.268820053046
Sphingolipid metabolism	C00065	3.56696428571	0.268820053046
Catecholamine biosynthesis	C00082	3.56696428571	0.268820053046
Carnitine synthesis	C00037	3.12109375	0.298412349855
Glutamate metabolism	C00144	2.9375	0.312730465165
Insulin signalling	C00020	2.77430555556	0.326739556402
Inositol metabolism	C04006	2.77430555556	0.326739556402
Inositol phosphate metabolism	C04006	2.62828947368	0.340446655254
Hypoacetylaspartia	C00041	2.62828947368	0.340446655254
Histidine metabolism	C00020	2.17119565217	0.392389960596
Pyrimidine metabolism	C00881	1.42678571429	0.523821316553
Tyrosine metabolism	C00082	1.34966216216	0.542623257645
Bile acid biosynthesis	C00037	1.04036458333	0.632902893897

Pathway	hits	oddsratio	pvalue
Alpha linolenic acid and linoleic acid metabolism	C06427,C03242,C01595,C06428	14.5272727273	0.000910089861541
Phenylketonuria	C00166,C00079	12.1060606061	0.0259348978847
5-oxoprolinuria	C01879	inf	0.0533175355451
Ornithine aminotransferase deficiency (oat deficiency)	C00077	inf	0.0533175355451
Fatty acid biosynthesis	C00249,C06424,C06423,C02679	2.59415584416	0.0923543379257
Tyrosinemia type 3 (tyro3)	C00079	18.1590909091	0.103732578031
Tyrosinemia type 2 (or richner-hanhart syndrome)	C00079	18.1590909091	0.103732578031
Dihydropyrimidinase deficiency	C02642	18.1590909091	0.103732578031
S-adenosylhomocysteine (sah) hydrolase deficiency	C00021	18.1590909091	0.103732578031
Beta ureidopropionase deficiency	C02642	18.1590909091	0.103732578031
Phenylalanine and tyrosine metabolism	C00166,C00079	3.30165289256	0.151291233984
Maple syrup urine disease	C00671	9.07954545455	0.151406377072
Glutathione synthetase deficiency	C01879	9.07954545455	0.151406377072
Beta oxidation of very long chain fatty acids	C06423,C02679	3.02651515152	0.170381243524
Hyperprolinemia type ii	C00077	6.05303030303	0.19649104417
Obesity / metabolic syndrome	C00249	6.05303030303	0.19649104417
Carnitine synthesis	C01181,C00021	2.42121212121	0.229340625529
Homocysteine degradation	C00109	3.02651515152	0.317605169898
Ornithine transcarbamylase deficiency (otc deficiency)	C00077	3.02651515152	0.317605169898
Methionine metabolism	C00021,C00109	1.65082644628	0.367454343649
Galactose metabolism	C00159,C00089	1.5790513834	0.386488920524
Riboflavin metabolism	C00255	2.26988636364	0.387825620672
Spermidine and spermine biosynthesis	C00077	2.26988636364	0.387825620672
Glutathione metabolism	C01879	2.01767676768	0.420120869288
Betaine metabolism	C00021	2.01767676768	0.420120869288
Transcription/translation	C00078,C00079	1.39685314685	0.441823467991
Beta-alanine metabolism	C02642	1.51325757576	0.506946411721
2-oxobutanoate degradation	C00109	1.51325757576	0.506946411721
Starch and sucrose metabolism	C00089	1.39685314685	0.532836040042
Ammonia recycling	C00785	1.06818181818	0.623252833475
Fructose and mannose degradation	C00159	1.06818181818	0.623252833475
Insulin signalling	C00249	1.00883838384	0.642920608989
Glycerolipid metabolism	C00249	1.00883838384	0.642920608989
Urea cycle	C00077	0.955741626794	0.66154004421
Citric acid cycle	C00417	0.82541322314	0.711662942138
Histidine metabolism	C00785	0.7895256917	0.726628533375
Prolidase deficiency(pd)	C00077	0.756628787879	0.740801017244
Fatty acid elongation in mitochondria	C00249	0.726363636364	0.754223289078
Glycine, serine and threonine metabolism	C00109	0.726363636364	0.754223289078
Arginine and proline metabolism	C00077	0.726363636364	0.754223289078
Fatty acid metabolism	C00249	0.648538961039	0.790383077349
Tryptophan metabolism	C00078	0.550275482094	0.839018406583
Pyrimidine metabolism	C02642	0.518831168831	0.855088156008
Valine, leucine and isoleucine degradation	C00671	0.518831168831	0.855088156008

Pathway	hits	oddsratio	pvalue
Lactose synthesis		nan	1.0
Intracellular signalling through pgd2 receptor and prostaglandin d2		nan	1.0
Glycine n-methyltransferase deficiency		nan	1.0
3-methylglutaconic aciduria type i		nan	1.0
Oxidation of branched chain fatty acids		nan	1.0
Caffeine metabolism		nan	1.0
Glycerol phosphate shuttle		nan	1.0
Pentose phosphate pathway		nan	1.0
Sphingolipid metabolism		nan	1.0
Tyrosinemia type 3 (tyro3)		nan	1.0
Excitatory neural signalling through 5-htr 6 and serotonin		nan	1.0
Nucleotide sugars metabolism		nan	1.0
Fructose and mannose degradation		nan	1.0
3-hydroxy-3-methylglutaryl-coa lyase deficiency		nan	1.0
Ethylmalonic encephalopathy		nan	1.0
Aspartylglucosaminuria		nan	1.0
Vinblastine pathway		nan	1.0
Alpha linolenic acid and linoleic acid metabolism		nan	1.0
Adefovir dipivoxil pathway		nan	1.0
Aica-ribosiduria		nan	1.0
Fatty acid elongation in mitochondria		nan	1.0
Amino sugar metabolism		nan	1.0
Escitalopram pathway		nan	1.0
Ethanol degradation		nan	1.0
Androgen and estrogen metabolism		nan	1.0
Lactic acidemia		nan	1.0
Lysinuric protein intolerance		nan	1.0
Glutaric aciduria type i		nan	1.0
Riboflavin metabolism		nan	1.0
Non ketotic hyperglycinemia		nan	1.0
Phosphatidylinositol phosphate metabolism		nan	1.0
Propionic acidemia		nan	1.0
Globoid cell leukodystrophy		nan	1.0
Hyperprolinemia type ii		nan	1.0
Glycolysis		nan	1.0
Hypermethioninemia		nan	1.0
Sialidosis		nan	1.0
Glycine, serine and threonine metabolism		nan	1.0
Ammonia recycling		nan	1.0
Familial hypercholanemia (fhca)		nan	1.0
Nicotine pathway		nan	1.0
Thiamine metabolism		nan	1.0
Cysteine metabolism		nan	1.0
Urea cycle		nan	1.0
Steroid biosynthesis		nan	1.0
Purine nucleoside phosphorylase deficiency		nan	1.0
Pyruvate dehydrogenase complex deficiency		nan	1.0
Ubiquinone biosynthesis		nan	1.0
Catecholamine biosynthesis		nan	1.0
Arginine: glycine amidinotransferase deficiency (agat deficiency)		nan	1.0
Prolidase deficiency(pd)		nan	1.0
Acute intermittent porphyria		nan	1.0
Methionine metabolism		nan	1.0
Adenosine deaminase deficiency		nan	1.0
Acenocoumarol pathway		nan	1.0
Smith-lemli-opitz syndrome (slos)		nan	1.0
Phenylacetate metabolism		nan	1.0
Cerebrotendinous xanthomatosis (ctx)		nan	1.0
Beta oxidation of very long chain fatty acids		nan	1.0
Corticotropin activation of cortisol production		nan	1.0
Citric acid cycle		nan	1.0
Glutamate metabolism		nan	1.0
Intracellular signalling through fsh receptor and follicle stimulating hormone		nan	1.0
Short chain acyl coa dehydrogenase deficiency (scad deficiency)		nan	1.0
Zellweger syndrome		nan	1.0
Argininosuccinic aciduria		nan	1.0
Glycerolipid metabolism		nan	1.0
Maple syrup urine disease		nan	1.0
Leukotriene c4 synthesis deficiency		nan	1.0
One carbon pool by folate		nan	1.0
Nebivolol pathway		nan	1.0
Taurine and hypotaurine metabolism		nan	1.0
Desmosterolosis		nan	1.0
Tyrosinemia type i		nan	1.0
3-methylglutaconic aciduria type iv		nan	1.0
Adenylosuccinate lyase deficiency		nan	1.0
Intracellular signalling through adenosine receptor a2b and adenosine		nan	1.0
Lysosomal acid lipase deficiency (wolman disease)		nan	1.0
Folate and pterine biosynthesis		nan	1.0
Tyrosinemia type 2 (or richner-hanhart syndrome)		nan	1.0
Pantothenate and coa biosynthesis		nan	1.0
Histidinemia		nan	1.0
Congenital bile acid synthesis defect type ii		nan	1.0
Methylenetetrahydrofolate reductase deficiency (mthfrd)		nan	1.0
Metachromatic leukodystrophy (mld)		nan	1.0
3-methylcrotonyl coa carboxylase deficiency type i		nan	1.0
Glutathione metabolism		nan	1.0
Pyruvate decarboxylase e1 component deficiency (pdhe1 deficiency)		nan	1.0
Transfer of acetyl groups into mitochondria		nan	1.0
Adrenal hyperplasia type 3 or congenital adrenal hyperplasia due to 21-hydroxylase deficiency		nan	1.0
Hypoacetylaspartia		nan	1.0
4-hydroxybutyric aciduria/succinic semialdehyde dehydrogenase deficiency		nan	1.0
Hyperinsulinism-hyperammonemia syndrome		nan	1.0
Intracellular signalling through histamine h2 receptor and histamine		nan	1.0
Molybdenium cofactor deficiency		nan	1.0
Gliclazide pathway		nan	1.0
Hyperprolinemia type i		nan	1.0
5-oxoprolinuria		nan	1.0
Phenylketonuria		nan	1.0
Tenofovir pathway		nan	1.0
Tamoxifen pathway		nan	1.0
Guanidinoacetate methyltransferase deficiency (gamt deficiency)		nan	1.0
Glibenclamide pathway		nan	1.0
Citalopram pathway		nan	1.0
Congenital bile acid synthesis defect type iii		nan	1.0
Excitatory neural signalling through 5-htr 7 and serotonin		nan	1.0
3-methylglutaconic aciduria type iii		nan	1.0
Fluorouracil pathway		nan	1.0
Betaine metabolism		nan	1.0
Phenprocoumon pathway		nan	1.0
Repaglinide pathway		nan	1.0
Steroidogenesis		nan	1.0
Sialuria or french type sialuria		nan	1.0
Retinol metabolism		nan	1.0
Sarcosinemia		nan	1.0
Congenital erythropoietic porphyria (cep) or gunther disease		nan	1.0
Lesch-nyhan syndrome (lns)		nan	1.0
Galactose metabolism		nan	1.0
Phospholipid biosynthesis		nan	1.0
Histidine metabolism		nan	1.0
Insulin signalling		nan	1.0
Hawkinsinuria		nan	1.0
Paclitaxel pathway		nan	1.0
2-hydroxyglutric aciduria (d and l form)		nan	1.0
Gout or kelley-seegmiller syndrome		nan	1.0
Glycerol kinase deficiency		nan	1.0
Argininemia		nan	1.0
Spermidine and spermine biosynthesis		nan	1.0
Biotinidase deficiency		nan	1.0
Degradation of superoxides		nan	1.0
Intracellular signalling through prostacyclin receptor and prostacyclin		nan	1.0
Primary hyperoxaluria type i		nan	1.0
Citrullinemia type i		nan	1.0
Selenoamino acid metabolism		nan	1.0
Eplerenone pathway		nan	1.0
Nicotinate and nicotinamide metabolism		nan	1.0
Fatty acid metabolism		nan	1.0
Mngie (mitochondrial neurogastrointestinal encephalopathy)		nan	1.0
Galactosemia		nan	1.0
Excitatory neural signalling through 5-htr 4 and serotonin		nan	1.0
2-methyl-3-hydroxybutryl coa dehydrogenase deficiency		nan	1.0
Glucose transporter defect (sglt2)		nan	1.0
Pyruvaldehyde degradation		nan	1.0
Dihydropyrimidinase deficiency		nan	1.0
Canavan disease		nan	1.0
Glutathione synthetase deficiency		nan	1.0
Spironolactone pathway		nan	1.0
Beta-alanine metabolism		nan	1.0
Dimethylglycine dehydrogenase deficiency		nan	1.0
Lysine degradation		nan	1.0
Vincristine pathway		nan	1.0
S-adenosylhomocysteine (sah) hydrolase deficiency		nan	1.0
Tryptophan metabolism		nan	1.0
Iminoglycinuria		nan	1.0
Adrenal hyperplasia type 5 or congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency		nan	1.0
Warfarin pathway		nan	1.0
Biotin metabolism		nan	1.0
Ketone body metabolism		nan	1.0
Leigh syndrome		nan	1.0
Arachidonic acid metabolism		nan	1.0
Isovaleric aciduria		nan	1.0
Tyrosine metabolism		nan	1.0
Inositol metabolism		nan	1.0
Butyrate metabolism		nan	1.0
Vitamin k metabolism		nan	1.0
Vitamin a deficiency		nan	1.0
Aromatic l-aminoacid decarboxylase deficiency		nan	1.0
Alanine metabolism		nan	1.0
Gamma-glutamyltransferase deficiency		nan	1.0
Starch and sucrose metabolism		nan	1.0
Fatty acid biosynthesis		nan	1.0
17-beta hydroxysteroid dehydrogenase iii deficiency		nan	1.0
Methylmalonic aciduria		nan	1.0
Arginine and proline metabolism		nan	1.0
Fluoxetine pathway		nan	1.0
Alkaptonuria		nan	1.0
Gaba-transaminase deficiency		nan	1.0
Cystathionine beta-synthase deficiency		nan	1.0
Congenital lipoid adrenal hyperplasia (clah) or lipoid cah		nan	1.0
Dicumarol pathway		nan	1.0
Lactose intolerance		nan	1.0
Intracellular signalling through adenosine receptor a2a and adenosine		nan	1.0
Bile acid biosynthesis		nan	1.0
Malate-aspartate shuttle		nan	1.0
Propanoate metabolism		nan	1.0
Saccharopinuria/hyperlysinemia ii		nan	1.0
Phenylalanine and tyrosine metabolism		nan	1.0
Beta ureidopropionase deficiency		nan	1.0
Phytanic acid peroxisomal oxidation		nan	1.0
Malonic aciduria		nan	1.0
Vindesine pathway		nan	1.0
Docetaxel pathway		nan	1.0
Porphyria variegata (pv)		nan	1.0
Glutaric aciduria type iii		nan	1.0
Dihydropyrimidine dehydrogenase deficiency (dhpd)		nan	1.0
Prolinemia type ii		nan	1.0
Carnitine synthesis		nan	1.0
Glycogen storage disease type 1a (gsd1a) or von gierke ddisease		nan	1.0
Valine, leucine and isoleucine degradation		nan	1.0
Child syndrome		nan	1.0
Beta-ketothiolase deficiency		nan	1.0
Purine metabolism		nan	1.0
Vitamin b6 metabolism		nan	1.0
Methylmalonate semialdehyde dehydrogenase deficiency		nan	1.0
Obesity / metabolic syndrome		nan	1.0
D-arginine and d-ornithine metabolism		nan	1.0
Pyruvate carboxylase deficiency		nan	1.0
Homocysteine degradation		nan	1.0
Xanthine dehydrogenase deficiency (xanthinuria)		nan	1.0
Chondrodysplasia punctata ii, x linked dominant (cdpx2)		nan	1.0
Desipramine pathway		nan	1.0
Pyruvate metabolism		nan	1.0
Capecitabine pathway		nan	1.0
Intracellular signalling through lhcgr receptor and luteinizing hormone/choriogonadotropin		nan	1.0
Aspartate metabolism		nan	1.0
Salla disease/infantile sialic acid storage disease		nan	1.0
Pyrimidine metabolism		nan	1.0
Methionine adenosyltransferase deficiency		nan	1.0
Gluconeogenesis		nan	1.0
Ump synthase deiciency (orotic aciduria)		nan	1.0
Inositol phosphate metabolism		nan	1.0
Gaucher disease		nan	1.0
Nateglinide pathway		nan	1.0
Methylmalonic aciduria due to cobalamin-related disorders		nan	1.0
Renal glucosuria		nan	1.0
2-oxobutanoate degradation		nan	1.0
Ornithine aminotransferase deficiency (oat deficiency)		nan	1.0
Hereditary coproporphyria (hcp)		nan	1.0
Glucose-alanine cycle		nan	1.0
Hartnup disorder		nan	1.0
Ornithine transcarbamylase deficiency (otc deficiency)		nan	1.0
Vinorelbine pathway		nan	1.0
Sulfate/sulfite metabolism		nan	1.0
Mitochondrial electron transport chain		nan	1.0
Lactose degradation		nan	1.0
Transcription/translation		nan	1.0
Refsum disease		nan	1.0
Imipramine pathway		nan	1.0
Vasopressin regulation of water homeostasis		nan	1.0

Pathway	hits	oddsratio	pvalue
Lactose synthesis		nan	1.0
Intracellular signalling through pgd2 receptor and prostaglandin d2		nan	1.0
Glycine n-methyltransferase deficiency		nan	1.0
3-methylglutaconic aciduria type i		nan	1.0
Oxidation of branched chain fatty acids		nan	1.0
Caffeine metabolism		nan	1.0
Glycerol phosphate shuttle		nan	1.0
Pentose phosphate pathway		nan	1.0
Sphingolipid metabolism		nan	1.0
Tyrosinemia type 3 (tyro3)		nan	1.0
Excitatory neural signalling through 5-htr 6 and serotonin		nan	1.0
Nucleotide sugars metabolism		nan	1.0
Fructose and mannose degradation		nan	1.0
3-hydroxy-3-methylglutaryl-coa lyase deficiency		nan	1.0
Ethylmalonic encephalopathy		nan	1.0
Aspartylglucosaminuria		nan	1.0
Vinblastine pathway		nan	1.0
Alpha linolenic acid and linoleic acid metabolism		nan	1.0
Adefovir dipivoxil pathway		nan	1.0
Aica-ribosiduria		nan	1.0
Fatty acid elongation in mitochondria		nan	1.0
Amino sugar metabolism		nan	1.0
Escitalopram pathway		nan	1.0
Ethanol degradation		nan	1.0
Androgen and estrogen metabolism		nan	1.0
Lactic acidemia		nan	1.0
Lysinuric protein intolerance		nan	1.0
Glutaric aciduria type i		nan	1.0
Riboflavin metabolism		nan	1.0
Non ketotic hyperglycinemia		nan	1.0
Phosphatidylinositol phosphate metabolism		nan	1.0
Propionic acidemia		nan	1.0
Globoid cell leukodystrophy		nan	1.0
Hyperprolinemia type ii		nan	1.0
Glycolysis		nan	1.0
Hypermethioninemia		nan	1.0
Sialidosis		nan	1.0
Glycine, serine and threonine metabolism		nan	1.0
Ammonia recycling		nan	1.0
Familial hypercholanemia (fhca)		nan	1.0
Nicotine pathway		nan	1.0
Thiamine metabolism		nan	1.0
Cysteine metabolism		nan	1.0
Urea cycle		nan	1.0
Steroid biosynthesis		nan	1.0
Purine nucleoside phosphorylase deficiency		nan	1.0
Pyruvate dehydrogenase complex deficiency		nan	1.0
Ubiquinone biosynthesis		nan	1.0
Catecholamine biosynthesis		nan	1.0
Arginine: glycine amidinotransferase deficiency (agat deficiency)		nan	1.0
Prolidase deficiency(pd)		nan	1.0
Acute intermittent porphyria		nan	1.0
Methionine metabolism		nan	1.0
Adenosine deaminase deficiency		nan	1.0
Acenocoumarol pathway		nan	1.0
Smith-lemli-opitz syndrome (slos)		nan	1.0
Phenylacetate metabolism		nan	1.0
Cerebrotendinous xanthomatosis (ctx)		nan	1.0
Beta oxidation of very long chain fatty acids		nan	1.0
Corticotropin activation of cortisol production		nan	1.0
Citric acid cycle		nan	1.0
Glutamate metabolism		nan	1.0
Intracellular signalling through fsh receptor and follicle stimulating hormone		nan	1.0
Short chain acyl coa dehydrogenase deficiency (scad deficiency)		nan	1.0
Zellweger syndrome		nan	1.0
Argininosuccinic aciduria		nan	1.0
Glycerolipid metabolism		nan	1.0
Maple syrup urine disease		nan	1.0
Leukotriene c4 synthesis deficiency		nan	1.0
One carbon pool by folate		nan	1.0
Nebivolol pathway		nan	1.0
Taurine and hypotaurine metabolism		nan	1.0
Desmosterolosis		nan	1.0
Tyrosinemia type i		nan	1.0
3-methylglutaconic aciduria type iv		nan	1.0
Adenylosuccinate lyase deficiency		nan	1.0
Intracellular signalling through adenosine receptor a2b and adenosine		nan	1.0
Lysosomal acid lipase deficiency (wolman disease)		nan	1.0
Folate and pterine biosynthesis		nan	1.0
Tyrosinemia type 2 (or richner-hanhart syndrome)		nan	1.0
Pantothenate and coa biosynthesis		nan	1.0
Histidinemia		nan	1.0
Congenital bile acid synthesis defect type ii		nan	1.0
Methylenetetrahydrofolate reductase deficiency (mthfrd)		nan	1.0
Metachromatic leukodystrophy (mld)		nan	1.0
3-methylcrotonyl coa carboxylase deficiency type i		nan	1.0
Glutathione metabolism		nan	1.0
Pyruvate decarboxylase e1 component deficiency (pdhe1 deficiency)		nan	1.0
Transfer of acetyl groups into mitochondria		nan	1.0
Adrenal hyperplasia type 3 or congenital adrenal hyperplasia due to 21-hydroxylase deficiency		nan	1.0
Hypoacetylaspartia		nan	1.0
4-hydroxybutyric aciduria/succinic semialdehyde dehydrogenase deficiency		nan	1.0
Hyperinsulinism-hyperammonemia syndrome		nan	1.0
Intracellular signalling through histamine h2 receptor and histamine		nan	1.0
Molybdenium cofactor deficiency		nan	1.0
Gliclazide pathway		nan	1.0
Hyperprolinemia type i		nan	1.0
5-oxoprolinuria		nan	1.0
Phenylketonuria		nan	1.0
Tenofovir pathway		nan	1.0
Tamoxifen pathway		nan	1.0
Guanidinoacetate methyltransferase deficiency (gamt deficiency)		nan	1.0
Glibenclamide pathway		nan	1.0
Citalopram pathway		nan	1.0
Congenital bile acid synthesis defect type iii		nan	1.0
Excitatory neural signalling through 5-htr 7 and serotonin		nan	1.0
3-methylglutaconic aciduria type iii		nan	1.0
Fluorouracil pathway		nan	1.0
Betaine metabolism		nan	1.0
Phenprocoumon pathway		nan	1.0
Repaglinide pathway		nan	1.0
Steroidogenesis		nan	1.0
Sialuria or french type sialuria		nan	1.0
Retinol metabolism		nan	1.0
Sarcosinemia		nan	1.0
Congenital erythropoietic porphyria (cep) or gunther disease		nan	1.0
Lesch-nyhan syndrome (lns)		nan	1.0
Galactose metabolism		nan	1.0
Phospholipid biosynthesis		nan	1.0
Histidine metabolism		nan	1.0
Insulin signalling		nan	1.0
Hawkinsinuria		nan	1.0
Paclitaxel pathway		nan	1.0
2-hydroxyglutric aciduria (d and l form)		nan	1.0
Gout or kelley-seegmiller syndrome		nan	1.0
Glycerol kinase deficiency		nan	1.0
Argininemia		nan	1.0
Spermidine and spermine biosynthesis		nan	1.0
Biotinidase deficiency		nan	1.0
Degradation of superoxides		nan	1.0
Intracellular signalling through prostacyclin receptor and prostacyclin		nan	1.0
Primary hyperoxaluria type i		nan	1.0
Citrullinemia type i		nan	1.0
Selenoamino acid metabolism		nan	1.0
Eplerenone pathway		nan	1.0
Nicotinate and nicotinamide metabolism		nan	1.0
Fatty acid metabolism		nan	1.0
Mngie (mitochondrial neurogastrointestinal encephalopathy)		nan	1.0
Galactosemia		nan	1.0
Excitatory neural signalling through 5-htr 4 and serotonin		nan	1.0
2-methyl-3-hydroxybutryl coa dehydrogenase deficiency		nan	1.0
Glucose transporter defect (sglt2)		nan	1.0
Pyruvaldehyde degradation		nan	1.0
Dihydropyrimidinase deficiency		nan	1.0
Canavan disease		nan	1.0
Glutathione synthetase deficiency		nan	1.0
Spironolactone pathway		nan	1.0
Beta-alanine metabolism		nan	1.0
Dimethylglycine dehydrogenase deficiency		nan	1.0
Lysine degradation		nan	1.0
Vincristine pathway		nan	1.0
S-adenosylhomocysteine (sah) hydrolase deficiency		nan	1.0
Tryptophan metabolism		nan	1.0
Iminoglycinuria		nan	1.0
Adrenal hyperplasia type 5 or congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency		nan	1.0
Warfarin pathway		nan	1.0
Biotin metabolism		nan	1.0
Ketone body metabolism		nan	1.0
Leigh syndrome		nan	1.0
Arachidonic acid metabolism		nan	1.0
Isovaleric aciduria		nan	1.0
Tyrosine metabolism		nan	1.0
Inositol metabolism		nan	1.0
Butyrate metabolism		nan	1.0
Vitamin k metabolism		nan	1.0
Vitamin a deficiency		nan	1.0
Aromatic l-aminoacid decarboxylase deficiency		nan	1.0
Alanine metabolism		nan	1.0
Gamma-glutamyltransferase deficiency		nan	1.0
Starch and sucrose metabolism		nan	1.0
Fatty acid biosynthesis		nan	1.0
17-beta hydroxysteroid dehydrogenase iii deficiency		nan	1.0
Methylmalonic aciduria		nan	1.0
Arginine and proline metabolism		nan	1.0
Fluoxetine pathway		nan	1.0
Alkaptonuria		nan	1.0
Gaba-transaminase deficiency		nan	1.0
Cystathionine beta-synthase deficiency		nan	1.0
Congenital lipoid adrenal hyperplasia (clah) or lipoid cah		nan	1.0
Dicumarol pathway		nan	1.0
Lactose intolerance		nan	1.0
Intracellular signalling through adenosine receptor a2a and adenosine		nan	1.0
Bile acid biosynthesis		nan	1.0
Malate-aspartate shuttle		nan	1.0
Propanoate metabolism		nan	1.0
Saccharopinuria/hyperlysinemia ii		nan	1.0
Phenylalanine and tyrosine metabolism		nan	1.0
Beta ureidopropionase deficiency		nan	1.0
Phytanic acid peroxisomal oxidation		nan	1.0
Malonic aciduria		nan	1.0
Vindesine pathway		nan	1.0
Docetaxel pathway		nan	1.0
Porphyria variegata (pv)		nan	1.0
Glutaric aciduria type iii		nan	1.0
Dihydropyrimidine dehydrogenase deficiency (dhpd)		nan	1.0
Prolinemia type ii		nan	1.0
Carnitine synthesis		nan	1.0
Glycogen storage disease type 1a (gsd1a) or von gierke ddisease		nan	1.0
Valine, leucine and isoleucine degradation		nan	1.0
Child syndrome		nan	1.0
Beta-ketothiolase deficiency		nan	1.0
Purine metabolism		nan	1.0
Vitamin b6 metabolism		nan	1.0
Methylmalonate semialdehyde dehydrogenase deficiency		nan	1.0
Obesity / metabolic syndrome		nan	1.0
D-arginine and d-ornithine metabolism		nan	1.0
Pyruvate carboxylase deficiency		nan	1.0
Homocysteine degradation		nan	1.0
Xanthine dehydrogenase deficiency (xanthinuria)		nan	1.0
Chondrodysplasia punctata ii, x linked dominant (cdpx2)		nan	1.0
Desipramine pathway		nan	1.0
Pyruvate metabolism		nan	1.0
Capecitabine pathway		nan	1.0
Intracellular signalling through lhcgr receptor and luteinizing hormone/choriogonadotropin		nan	1.0
Aspartate metabolism		nan	1.0
Salla disease/infantile sialic acid storage disease		nan	1.0
Pyrimidine metabolism		nan	1.0
Methionine adenosyltransferase deficiency		nan	1.0
Gluconeogenesis		nan	1.0
Ump synthase deiciency (orotic aciduria)		nan	1.0
Inositol phosphate metabolism		nan	1.0
Gaucher disease		nan	1.0
Nateglinide pathway		nan	1.0
Methylmalonic aciduria due to cobalamin-related disorders		nan	1.0
Renal glucosuria		nan	1.0
2-oxobutanoate degradation		nan	1.0
Ornithine aminotransferase deficiency (oat deficiency)		nan	1.0
Hereditary coproporphyria (hcp)		nan	1.0
Glucose-alanine cycle		nan	1.0
Hartnup disorder		nan	1.0
Ornithine transcarbamylase deficiency (otc deficiency)		nan	1.0
Vinorelbine pathway		nan	1.0
Sulfate/sulfite metabolism		nan	1.0
Mitochondrial electron transport chain		nan	1.0
Lactose degradation		nan	1.0
Transcription/translation		nan	1.0
Refsum disease		nan	1.0
Imipramine pathway		nan	1.0
Vasopressin regulation of water homeostasis		nan	1.0

Pathway	hits	oddsratio	pvalue
Lysine degradation	C00956	66.5833333333	0.0317440120215
Glutaric aciduria type iii	C00956	61.4615384615	0.0341230193629

Pathway	hits	oddsratio	pvalue
Lactose synthesis		nan	1.0
Intracellular signalling through pgd2 receptor and prostaglandin d2		nan	1.0
Glycine n-methyltransferase deficiency		nan	1.0
3-methylglutaconic aciduria type i		nan	1.0
Oxidation of branched chain fatty acids		nan	1.0
Caffeine metabolism		nan	1.0
Glycerol phosphate shuttle		nan	1.0
Pentose phosphate pathway		nan	1.0
Sphingolipid metabolism		nan	1.0
Tyrosinemia type 3 (tyro3)		nan	1.0
Excitatory neural signalling through 5-htr 6 and serotonin		nan	1.0
Nucleotide sugars metabolism		nan	1.0
Fructose and mannose degradation		nan	1.0
3-hydroxy-3-methylglutaryl-coa lyase deficiency		nan	1.0
Ethylmalonic encephalopathy		nan	1.0
Aspartylglucosaminuria		nan	1.0
Vinblastine pathway		nan	1.0
Alpha linolenic acid and linoleic acid metabolism		nan	1.0
Adefovir dipivoxil pathway		nan	1.0
Aica-ribosiduria		nan	1.0
Fatty acid elongation in mitochondria		nan	1.0
Amino sugar metabolism		nan	1.0
Escitalopram pathway		nan	1.0
Ethanol degradation		nan	1.0
Androgen and estrogen metabolism		nan	1.0
Lactic acidemia		nan	1.0
Lysinuric protein intolerance		nan	1.0
Glutaric aciduria type i		nan	1.0
Riboflavin metabolism		nan	1.0
Non ketotic hyperglycinemia		nan	1.0
Phosphatidylinositol phosphate metabolism		nan	1.0
Propionic acidemia		nan	1.0
Globoid cell leukodystrophy		nan	1.0
Hyperprolinemia type ii		nan	1.0
Glycolysis		nan	1.0
Hypermethioninemia		nan	1.0
Sialidosis		nan	1.0
Glycine, serine and threonine metabolism		nan	1.0
Ammonia recycling		nan	1.0
Familial hypercholanemia (fhca)		nan	1.0
Nicotine pathway		nan	1.0
Thiamine metabolism		nan	1.0
Cysteine metabolism		nan	1.0
Urea cycle		nan	1.0
Steroid biosynthesis		nan	1.0
Purine nucleoside phosphorylase deficiency		nan	1.0
Pyruvate dehydrogenase complex deficiency		nan	1.0
Ubiquinone biosynthesis		nan	1.0
Catecholamine biosynthesis		nan	1.0
Arginine: glycine amidinotransferase deficiency (agat deficiency)		nan	1.0
Prolidase deficiency(pd)		nan	1.0
Acute intermittent porphyria		nan	1.0
Methionine metabolism		nan	1.0
Adenosine deaminase deficiency		nan	1.0
Acenocoumarol pathway		nan	1.0
Smith-lemli-opitz syndrome (slos)		nan	1.0
Phenylacetate metabolism		nan	1.0
Cerebrotendinous xanthomatosis (ctx)		nan	1.0
Beta oxidation of very long chain fatty acids		nan	1.0
Corticotropin activation of cortisol production		nan	1.0
Citric acid cycle		nan	1.0
Glutamate metabolism		nan	1.0
Intracellular signalling through fsh receptor and follicle stimulating hormone		nan	1.0
Short chain acyl coa dehydrogenase deficiency (scad deficiency)		nan	1.0
Zellweger syndrome		nan	1.0
Argininosuccinic aciduria		nan	1.0
Glycerolipid metabolism		nan	1.0
Maple syrup urine disease		nan	1.0
Leukotriene c4 synthesis deficiency		nan	1.0
One carbon pool by folate		nan	1.0
Nebivolol pathway		nan	1.0
Taurine and hypotaurine metabolism		nan	1.0
Desmosterolosis		nan	1.0
Tyrosinemia type i		nan	1.0
3-methylglutaconic aciduria type iv		nan	1.0
Adenylosuccinate lyase deficiency		nan	1.0
Intracellular signalling through adenosine receptor a2b and adenosine		nan	1.0
Lysosomal acid lipase deficiency (wolman disease)		nan	1.0
Folate and pterine biosynthesis		nan	1.0
Tyrosinemia type 2 (or richner-hanhart syndrome)		nan	1.0
Pantothenate and coa biosynthesis		nan	1.0
Histidinemia		nan	1.0
Congenital bile acid synthesis defect type ii		nan	1.0
Methylenetetrahydrofolate reductase deficiency (mthfrd)		nan	1.0
Metachromatic leukodystrophy (mld)		nan	1.0
3-methylcrotonyl coa carboxylase deficiency type i		nan	1.0
Glutathione metabolism		nan	1.0
Pyruvate decarboxylase e1 component deficiency (pdhe1 deficiency)		nan	1.0
Transfer of acetyl groups into mitochondria		nan	1.0
Adrenal hyperplasia type 3 or congenital adrenal hyperplasia due to 21-hydroxylase deficiency		nan	1.0
Hypoacetylaspartia		nan	1.0
4-hydroxybutyric aciduria/succinic semialdehyde dehydrogenase deficiency		nan	1.0
Hyperinsulinism-hyperammonemia syndrome		nan	1.0
Intracellular signalling through histamine h2 receptor and histamine		nan	1.0
Molybdenium cofactor deficiency		nan	1.0
Gliclazide pathway		nan	1.0
Hyperprolinemia type i		nan	1.0
5-oxoprolinuria		nan	1.0
Phenylketonuria		nan	1.0
Tenofovir pathway		nan	1.0
Tamoxifen pathway		nan	1.0
Guanidinoacetate methyltransferase deficiency (gamt deficiency)		nan	1.0
Glibenclamide pathway		nan	1.0
Citalopram pathway		nan	1.0
Congenital bile acid synthesis defect type iii		nan	1.0
Excitatory neural signalling through 5-htr 7 and serotonin		nan	1.0
3-methylglutaconic aciduria type iii		nan	1.0
Fluorouracil pathway		nan	1.0
Betaine metabolism		nan	1.0
Phenprocoumon pathway		nan	1.0
Repaglinide pathway		nan	1.0
Steroidogenesis		nan	1.0
Sialuria or french type sialuria		nan	1.0
Retinol metabolism		nan	1.0
Sarcosinemia		nan	1.0
Congenital erythropoietic porphyria (cep) or gunther disease		nan	1.0
Lesch-nyhan syndrome (lns)		nan	1.0
Galactose metabolism		nan	1.0
Phospholipid biosynthesis		nan	1.0
Histidine metabolism		nan	1.0
Insulin signalling		nan	1.0
Hawkinsinuria		nan	1.0
Paclitaxel pathway		nan	1.0
2-hydroxyglutric aciduria (d and l form)		nan	1.0
Gout or kelley-seegmiller syndrome		nan	1.0
Glycerol kinase deficiency		nan	1.0
Argininemia		nan	1.0
Spermidine and spermine biosynthesis		nan	1.0
Biotinidase deficiency		nan	1.0
Degradation of superoxides		nan	1.0
Intracellular signalling through prostacyclin receptor and prostacyclin		nan	1.0
Primary hyperoxaluria type i		nan	1.0
Citrullinemia type i		nan	1.0
Selenoamino acid metabolism		nan	1.0
Eplerenone pathway		nan	1.0
Nicotinate and nicotinamide metabolism		nan	1.0
Fatty acid metabolism		nan	1.0
Mngie (mitochondrial neurogastrointestinal encephalopathy)		nan	1.0
Galactosemia		nan	1.0
Excitatory neural signalling through 5-htr 4 and serotonin		nan	1.0
2-methyl-3-hydroxybutryl coa dehydrogenase deficiency		nan	1.0
Glucose transporter defect (sglt2)		nan	1.0
Pyruvaldehyde degradation		nan	1.0
Dihydropyrimidinase deficiency		nan	1.0
Canavan disease		nan	1.0
Glutathione synthetase deficiency		nan	1.0
Spironolactone pathway		nan	1.0
Beta-alanine metabolism		nan	1.0
Dimethylglycine dehydrogenase deficiency		nan	1.0
Lysine degradation		nan	1.0
Vincristine pathway		nan	1.0
S-adenosylhomocysteine (sah) hydrolase deficiency		nan	1.0
Tryptophan metabolism		nan	1.0
Iminoglycinuria		nan	1.0
Adrenal hyperplasia type 5 or congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency		nan	1.0
Warfarin pathway		nan	1.0
Biotin metabolism		nan	1.0
Ketone body metabolism		nan	1.0
Leigh syndrome		nan	1.0
Arachidonic acid metabolism		nan	1.0
Isovaleric aciduria		nan	1.0
Tyrosine metabolism		nan	1.0
Inositol metabolism		nan	1.0
Butyrate metabolism		nan	1.0
Vitamin k metabolism		nan	1.0
Vitamin a deficiency		nan	1.0
Aromatic l-aminoacid decarboxylase deficiency		nan	1.0
Alanine metabolism		nan	1.0
Gamma-glutamyltransferase deficiency		nan	1.0
Starch and sucrose metabolism		nan	1.0
Fatty acid biosynthesis		nan	1.0
17-beta hydroxysteroid dehydrogenase iii deficiency		nan	1.0
Methylmalonic aciduria		nan	1.0
Arginine and proline metabolism		nan	1.0
Fluoxetine pathway		nan	1.0
Alkaptonuria		nan	1.0
Gaba-transaminase deficiency		nan	1.0
Cystathionine beta-synthase deficiency		nan	1.0
Congenital lipoid adrenal hyperplasia (clah) or lipoid cah		nan	1.0
Dicumarol pathway		nan	1.0
Lactose intolerance		nan	1.0
Intracellular signalling through adenosine receptor a2a and adenosine		nan	1.0
Bile acid biosynthesis		nan	1.0
Malate-aspartate shuttle		nan	1.0
Propanoate metabolism		nan	1.0
Saccharopinuria/hyperlysinemia ii		nan	1.0
Phenylalanine and tyrosine metabolism		nan	1.0
Beta ureidopropionase deficiency		nan	1.0
Phytanic acid peroxisomal oxidation		nan	1.0
Malonic aciduria		nan	1.0
Vindesine pathway		nan	1.0
Docetaxel pathway		nan	1.0
Porphyria variegata (pv)		nan	1.0
Glutaric aciduria type iii		nan	1.0
Dihydropyrimidine dehydrogenase deficiency (dhpd)		nan	1.0
Prolinemia type ii		nan	1.0
Carnitine synthesis		nan	1.0
Glycogen storage disease type 1a (gsd1a) or von gierke ddisease		nan	1.0
Valine, leucine and isoleucine degradation		nan	1.0
Child syndrome		nan	1.0
Beta-ketothiolase deficiency		nan	1.0
Purine metabolism		nan	1.0
Vitamin b6 metabolism		nan	1.0
Methylmalonate semialdehyde dehydrogenase deficiency		nan	1.0
Obesity / metabolic syndrome		nan	1.0
D-arginine and d-ornithine metabolism		nan	1.0
Pyruvate carboxylase deficiency		nan	1.0
Homocysteine degradation		nan	1.0
Xanthine dehydrogenase deficiency (xanthinuria)		nan	1.0
Chondrodysplasia punctata ii, x linked dominant (cdpx2)		nan	1.0
Desipramine pathway		nan	1.0
Pyruvate metabolism		nan	1.0
Capecitabine pathway		nan	1.0
Intracellular signalling through lhcgr receptor and luteinizing hormone/choriogonadotropin		nan	1.0
Aspartate metabolism		nan	1.0
Salla disease/infantile sialic acid storage disease		nan	1.0
Pyrimidine metabolism		nan	1.0
Methionine adenosyltransferase deficiency		nan	1.0
Gluconeogenesis		nan	1.0
Ump synthase deiciency (orotic aciduria)		nan	1.0
Inositol phosphate metabolism		nan	1.0
Gaucher disease		nan	1.0
Nateglinide pathway		nan	1.0
Methylmalonic aciduria due to cobalamin-related disorders		nan	1.0
Renal glucosuria		nan	1.0
2-oxobutanoate degradation		nan	1.0
Ornithine aminotransferase deficiency (oat deficiency)		nan	1.0
Hereditary coproporphyria (hcp)		nan	1.0
Glucose-alanine cycle		nan	1.0
Hartnup disorder		nan	1.0
Ornithine transcarbamylase deficiency (otc deficiency)		nan	1.0
Vinorelbine pathway		nan	1.0
Sulfate/sulfite metabolism		nan	1.0
Mitochondrial electron transport chain		nan	1.0
Lactose degradation		nan	1.0
Transcription/translation		nan	1.0
Refsum disease		nan	1.0
Imipramine pathway		nan	1.0
Vasopressin regulation of water homeostasis		nan	1.0

Pathway	hits	oddsratio	pvalue
Lactose synthesis		0.0	1.0
Intracellular signalling through pgd2 receptor and prostaglandin d2		0.0	1.0
Glycine n-methyltransferase deficiency		0.0	1.0
3-methylglutaconic aciduria type i		0.0	1.0
Oxidation of branched chain fatty acids		0.0	1.0
Caffeine metabolism		0.0	1.0
Glycerol phosphate shuttle		0.0	1.0
Pentose phosphate pathway		0.0	1.0
Sphingolipid metabolism		0.0	1.0
Tyrosinemia type 3 (tyro3)		0.0	1.0
Excitatory neural signalling through 5-htr 6 and serotonin		0.0	1.0
Nucleotide sugars metabolism		0.0	1.0
Fructose and mannose degradation		0.0	1.0
3-hydroxy-3-methylglutaryl-coa lyase deficiency		0.0	1.0
Ethylmalonic encephalopathy		0.0	1.0
Aspartylglucosaminuria		0.0	1.0
Vinblastine pathway		0.0	1.0
Alpha linolenic acid and linoleic acid metabolism		0.0	1.0
Adefovir dipivoxil pathway		0.0	1.0
Aica-ribosiduria		0.0	1.0
Fatty acid elongation in mitochondria		0.0	1.0
Amino sugar metabolism		0.0	1.0
Escitalopram pathway		0.0	1.0
Ethanol degradation		0.0	1.0
Androgen and estrogen metabolism		0.0	1.0
Lactic acidemia		0.0	1.0
Lysinuric protein intolerance		0.0	1.0
Glutaric aciduria type i		0.0	1.0
Riboflavin metabolism		0.0	1.0
Non ketotic hyperglycinemia		0.0	1.0
Phosphatidylinositol phosphate metabolism		0.0	1.0
Propionic acidemia		0.0	1.0
Globoid cell leukodystrophy		0.0	1.0
Hyperprolinemia type ii		0.0	1.0
Glycolysis		0.0	1.0
Hypermethioninemia		0.0	1.0
Sialidosis		0.0	1.0
Glycine, serine and threonine metabolism		0.0	1.0
Ammonia recycling		0.0	1.0
Familial hypercholanemia (fhca)		0.0	1.0
Nicotine pathway		0.0	1.0
Thiamine metabolism		0.0	1.0
Cysteine metabolism		0.0	1.0
Urea cycle		0.0	1.0
Steroid biosynthesis		0.0	1.0
Purine nucleoside phosphorylase deficiency		0.0	1.0
Pyruvate dehydrogenase complex deficiency		0.0	1.0
Ubiquinone biosynthesis		0.0	1.0
Catecholamine biosynthesis		0.0	1.0
Arginine: glycine amidinotransferase deficiency (agat deficiency)		0.0	1.0
Prolidase deficiency(pd)		0.0	1.0
Acute intermittent porphyria		0.0	1.0
Methionine metabolism		0.0	1.0
Adenosine deaminase deficiency		0.0	1.0
Acenocoumarol pathway		0.0	1.0
Smith-lemli-opitz syndrome (slos)		0.0	1.0
Phenylacetate metabolism		0.0	1.0
Cerebrotendinous xanthomatosis (ctx)		0.0	1.0
Beta oxidation of very long chain fatty acids		0.0	1.0
Corticotropin activation of cortisol production		0.0	1.0
Citric acid cycle		0.0	1.0
Glutamate metabolism		0.0	1.0
Intracellular signalling through fsh receptor and follicle stimulating hormone		0.0	1.0
Short chain acyl coa dehydrogenase deficiency (scad deficiency)		0.0	1.0
Zellweger syndrome		0.0	1.0
Argininosuccinic aciduria		0.0	1.0
Glycerolipid metabolism		0.0	1.0
Maple syrup urine disease		0.0	1.0
Leukotriene c4 synthesis deficiency		0.0	1.0
One carbon pool by folate		0.0	1.0
Nebivolol pathway		0.0	1.0
Taurine and hypotaurine metabolism		0.0	1.0
Desmosterolosis		0.0	1.0
Tyrosinemia type i		0.0	1.0
3-methylglutaconic aciduria type iv		0.0	1.0
Adenylosuccinate lyase deficiency		0.0	1.0
Intracellular signalling through adenosine receptor a2b and adenosine		0.0	1.0
Lysosomal acid lipase deficiency (wolman disease)		0.0	1.0
Folate and pterine biosynthesis		0.0	1.0
Tyrosinemia type 2 (or richner-hanhart syndrome)		0.0	1.0
Pantothenate and coa biosynthesis		0.0	1.0
Histidinemia		0.0	1.0
Congenital bile acid synthesis defect type ii		0.0	1.0
Methylenetetrahydrofolate reductase deficiency (mthfrd)		0.0	1.0
Metachromatic leukodystrophy (mld)		0.0	1.0
3-methylcrotonyl coa carboxylase deficiency type i		0.0	1.0
Glutathione metabolism		0.0	1.0
Pyruvate decarboxylase e1 component deficiency (pdhe1 deficiency)		0.0	1.0
Transfer of acetyl groups into mitochondria		0.0	1.0
Adrenal hyperplasia type 3 or congenital adrenal hyperplasia due to 21-hydroxylase deficiency		0.0	1.0
Hypoacetylaspartia		0.0	1.0
4-hydroxybutyric aciduria/succinic semialdehyde dehydrogenase deficiency		0.0	1.0
Hyperinsulinism-hyperammonemia syndrome		0.0	1.0
Intracellular signalling through histamine h2 receptor and histamine		0.0	1.0
Molybdenium cofactor deficiency		0.0	1.0
Gliclazide pathway		0.0	1.0
Hyperprolinemia type i		0.0	1.0
5-oxoprolinuria		0.0	1.0
Phenylketonuria		0.0	1.0
Tenofovir pathway		0.0	1.0
Tamoxifen pathway		0.0	1.0
Guanidinoacetate methyltransferase deficiency (gamt deficiency)		0.0	1.0
Glibenclamide pathway		0.0	1.0
Citalopram pathway		0.0	1.0
Congenital bile acid synthesis defect type iii		0.0	1.0
Excitatory neural signalling through 5-htr 7 and serotonin		0.0	1.0
3-methylglutaconic aciduria type iii		0.0	1.0
Fluorouracil pathway		0.0	1.0
Betaine metabolism		0.0	1.0
Phenprocoumon pathway		0.0	1.0
Repaglinide pathway		0.0	1.0
Steroidogenesis		0.0	1.0
Sialuria or french type sialuria		0.0	1.0
Retinol metabolism		0.0	1.0
Sarcosinemia		0.0	1.0
Congenital erythropoietic porphyria (cep) or gunther disease		0.0	1.0
Lesch-nyhan syndrome (lns)		0.0	1.0
Galactose metabolism		0.0	1.0
Phospholipid biosynthesis		0.0	1.0
Histidine metabolism		0.0	1.0
Insulin signalling		0.0	1.0
Hawkinsinuria		0.0	1.0
Paclitaxel pathway		0.0	1.0
2-hydroxyglutric aciduria (d and l form)		0.0	1.0
Gout or kelley-seegmiller syndrome		0.0	1.0
Glycerol kinase deficiency		0.0	1.0
Argininemia		0.0	1.0
Spermidine and spermine biosynthesis		0.0	1.0
Biotinidase deficiency		0.0	1.0
Degradation of superoxides		0.0	1.0
Intracellular signalling through prostacyclin receptor and prostacyclin		0.0	1.0
Primary hyperoxaluria type i		0.0	1.0
Citrullinemia type i		0.0	1.0
Selenoamino acid metabolism		0.0	1.0
Eplerenone pathway		0.0	1.0
Nicotinate and nicotinamide metabolism		0.0	1.0
Fatty acid metabolism		0.0	1.0
Mngie (mitochondrial neurogastrointestinal encephalopathy)		0.0	1.0
Galactosemia		0.0	1.0
Excitatory neural signalling through 5-htr 4 and serotonin		0.0	1.0
2-methyl-3-hydroxybutryl coa dehydrogenase deficiency		0.0	1.0
Glucose transporter defect (sglt2)		0.0	1.0
Pyruvaldehyde degradation		0.0	1.0
Dihydropyrimidinase deficiency		0.0	1.0
Canavan disease		0.0	1.0
Glutathione synthetase deficiency		0.0	1.0
Spironolactone pathway		0.0	1.0
Beta-alanine metabolism		0.0	1.0
Dimethylglycine dehydrogenase deficiency		0.0	1.0
Lysine degradation		0.0	1.0
Vincristine pathway		0.0	1.0
S-adenosylhomocysteine (sah) hydrolase deficiency		0.0	1.0
Tryptophan metabolism		0.0	1.0
Iminoglycinuria		0.0	1.0
Adrenal hyperplasia type 5 or congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency		0.0	1.0
Warfarin pathway		0.0	1.0
Biotin metabolism		0.0	1.0
Ketone body metabolism		0.0	1.0
Leigh syndrome		0.0	1.0
Arachidonic acid metabolism		0.0	1.0
Isovaleric aciduria		0.0	1.0
Tyrosine metabolism		0.0	1.0
Inositol metabolism		0.0	1.0
Butyrate metabolism		0.0	1.0
Vitamin k metabolism		0.0	1.0
Vitamin a deficiency		0.0	1.0
Aromatic l-aminoacid decarboxylase deficiency		0.0	1.0
Alanine metabolism		0.0	1.0
Gamma-glutamyltransferase deficiency		0.0	1.0
Starch and sucrose metabolism		0.0	1.0
Fatty acid biosynthesis		0.0	1.0
17-beta hydroxysteroid dehydrogenase iii deficiency		0.0	1.0
Methylmalonic aciduria		0.0	1.0
Arginine and proline metabolism		0.0	1.0
Fluoxetine pathway		0.0	1.0
Alkaptonuria		0.0	1.0
Gaba-transaminase deficiency		0.0	1.0
Cystathionine beta-synthase deficiency		0.0	1.0
Congenital lipoid adrenal hyperplasia (clah) or lipoid cah		0.0	1.0
Dicumarol pathway		0.0	1.0
Lactose intolerance		0.0	1.0
Intracellular signalling through adenosine receptor a2a and adenosine		0.0	1.0
Bile acid biosynthesis		0.0	1.0
Malate-aspartate shuttle		0.0	1.0
Propanoate metabolism		0.0	1.0
Saccharopinuria/hyperlysinemia ii		0.0	1.0
Phenylalanine and tyrosine metabolism		0.0	1.0
Beta ureidopropionase deficiency		0.0	1.0
Phytanic acid peroxisomal oxidation		0.0	1.0
Malonic aciduria		0.0	1.0
Vindesine pathway		0.0	1.0
Docetaxel pathway		0.0	1.0
Porphyria variegata (pv)		0.0	1.0
Glutaric aciduria type iii		0.0	1.0
Dihydropyrimidine dehydrogenase deficiency (dhpd)		0.0	1.0
Prolinemia type ii		0.0	1.0
Carnitine synthesis		0.0	1.0
Glycogen storage disease type 1a (gsd1a) or von gierke ddisease		0.0	1.0
Valine, leucine and isoleucine degradation		0.0	1.0
Child syndrome		0.0	1.0
Beta-ketothiolase deficiency		0.0	1.0
Purine metabolism		0.0	1.0
Vitamin b6 metabolism		0.0	1.0
Methylmalonate semialdehyde dehydrogenase deficiency		0.0	1.0
Obesity / metabolic syndrome		0.0	1.0
D-arginine and d-ornithine metabolism		0.0	1.0
Pyruvate carboxylase deficiency		0.0	1.0
Homocysteine degradation		0.0	1.0
Xanthine dehydrogenase deficiency (xanthinuria)		0.0	1.0
Chondrodysplasia punctata ii, x linked dominant (cdpx2)		0.0	1.0
Desipramine pathway		0.0	1.0
Pyruvate metabolism		0.0	1.0
Capecitabine pathway		0.0	1.0
Intracellular signalling through lhcgr receptor and luteinizing hormone/choriogonadotropin		0.0	1.0
Aspartate metabolism		0.0	1.0
Salla disease/infantile sialic acid storage disease		0.0	1.0
Pyrimidine metabolism		0.0	1.0
Methionine adenosyltransferase deficiency		0.0	1.0
Gluconeogenesis		0.0	1.0
Ump synthase deiciency (orotic aciduria)		0.0	1.0
Inositol phosphate metabolism		0.0	1.0
Gaucher disease		0.0	1.0
Nateglinide pathway		0.0	1.0
Methylmalonic aciduria due to cobalamin-related disorders		0.0	1.0
Renal glucosuria		0.0	1.0
2-oxobutanoate degradation		0.0	1.0
Ornithine aminotransferase deficiency (oat deficiency)		0.0	1.0
Hereditary coproporphyria (hcp)		0.0	1.0
Glucose-alanine cycle		0.0	1.0
Hartnup disorder		0.0	1.0
Ornithine transcarbamylase deficiency (otc deficiency)		0.0	1.0
Vinorelbine pathway		0.0	1.0
Sulfate/sulfite metabolism		0.0	1.0
Mitochondrial electron transport chain		0.0	1.0
Lactose degradation		0.0	1.0
Transcription/translation		0.0	1.0
Refsum disease		0.0	1.0
Imipramine pathway		0.0	1.0
Vasopressin regulation of water homeostasis		0.0	1.0

Pathway	hits	oddsratio	pvalue
Lysine degradation	C00956	33.2916666667	0.0472075597411
Glutaric aciduria type iii	C00956	30.7307692308	0.0507147711775

Pathway	hits	oddsratio	pvalue
Lysine degradation	C00956	66.5833333333	0.0317440120215
Glutaric aciduria type iii	C00956	61.4615384615	0.0341230193629

Pathway	hits	oddsratio	pvalue
Lactose synthesis		0.0	1.0
Intracellular signalling through pgd2 receptor and prostaglandin d2		0.0	1.0
Glycine n-methyltransferase deficiency		0.0	1.0
3-methylglutaconic aciduria type i		0.0	1.0
Oxidation of branched chain fatty acids		0.0	1.0
Caffeine metabolism		0.0	1.0
Glycerol phosphate shuttle		0.0	1.0
Pentose phosphate pathway		0.0	1.0
Sphingolipid metabolism		0.0	1.0
Tyrosinemia type 3 (tyro3)		0.0	1.0
Excitatory neural signalling through 5-htr 6 and serotonin		0.0	1.0
Nucleotide sugars metabolism		0.0	1.0
Fructose and mannose degradation		0.0	1.0
3-hydroxy-3-methylglutaryl-coa lyase deficiency		0.0	1.0
Ethylmalonic encephalopathy		0.0	1.0
Aspartylglucosaminuria		0.0	1.0
Vinblastine pathway		0.0	1.0
Alpha linolenic acid and linoleic acid metabolism		0.0	1.0
Adefovir dipivoxil pathway		0.0	1.0
Aica-ribosiduria		0.0	1.0
Fatty acid elongation in mitochondria		0.0	1.0
Amino sugar metabolism		0.0	1.0
Escitalopram pathway		0.0	1.0
Ethanol degradation		0.0	1.0
Androgen and estrogen metabolism		0.0	1.0
Lactic acidemia		0.0	1.0
Lysinuric protein intolerance		0.0	1.0
Glutaric aciduria type i		0.0	1.0
Riboflavin metabolism		0.0	1.0
Non ketotic hyperglycinemia		0.0	1.0
Phosphatidylinositol phosphate metabolism		0.0	1.0
Propionic acidemia		0.0	1.0
Globoid cell leukodystrophy		0.0	1.0
Hyperprolinemia type ii		0.0	1.0
Glycolysis		0.0	1.0
Hypermethioninemia		0.0	1.0
Sialidosis		0.0	1.0
Glycine, serine and threonine metabolism		0.0	1.0
Ammonia recycling		0.0	1.0
Familial hypercholanemia (fhca)		0.0	1.0
Nicotine pathway		0.0	1.0
Thiamine metabolism		0.0	1.0
Cysteine metabolism		0.0	1.0
Urea cycle		0.0	1.0
Steroid biosynthesis		0.0	1.0
Purine nucleoside phosphorylase deficiency		0.0	1.0
Pyruvate dehydrogenase complex deficiency		0.0	1.0
Ubiquinone biosynthesis		0.0	1.0
Catecholamine biosynthesis		0.0	1.0
Arginine: glycine amidinotransferase deficiency (agat deficiency)		0.0	1.0
Prolidase deficiency(pd)		0.0	1.0
Acute intermittent porphyria		0.0	1.0
Methionine metabolism		0.0	1.0
Adenosine deaminase deficiency		0.0	1.0
Acenocoumarol pathway		0.0	1.0
Smith-lemli-opitz syndrome (slos)		0.0	1.0
Phenylacetate metabolism		0.0	1.0
Cerebrotendinous xanthomatosis (ctx)		0.0	1.0
Beta oxidation of very long chain fatty acids		0.0	1.0
Corticotropin activation of cortisol production		0.0	1.0
Citric acid cycle		0.0	1.0
Glutamate metabolism		0.0	1.0
Intracellular signalling through fsh receptor and follicle stimulating hormone		0.0	1.0
Short chain acyl coa dehydrogenase deficiency (scad deficiency)		0.0	1.0
Zellweger syndrome		0.0	1.0
Argininosuccinic aciduria		0.0	1.0
Glycerolipid metabolism		0.0	1.0
Maple syrup urine disease		0.0	1.0
Leukotriene c4 synthesis deficiency		0.0	1.0
One carbon pool by folate		0.0	1.0
Nebivolol pathway		0.0	1.0
Taurine and hypotaurine metabolism		0.0	1.0
Desmosterolosis		0.0	1.0
Tyrosinemia type i		0.0	1.0
3-methylglutaconic aciduria type iv		0.0	1.0
Adenylosuccinate lyase deficiency		0.0	1.0
Intracellular signalling through adenosine receptor a2b and adenosine		0.0	1.0
Lysosomal acid lipase deficiency (wolman disease)		0.0	1.0
Folate and pterine biosynthesis		0.0	1.0
Tyrosinemia type 2 (or richner-hanhart syndrome)		0.0	1.0
Pantothenate and coa biosynthesis		0.0	1.0
Histidinemia		0.0	1.0
Congenital bile acid synthesis defect type ii		0.0	1.0
Methylenetetrahydrofolate reductase deficiency (mthfrd)		0.0	1.0
Metachromatic leukodystrophy (mld)		0.0	1.0
3-methylcrotonyl coa carboxylase deficiency type i		0.0	1.0
Glutathione metabolism		0.0	1.0
Pyruvate decarboxylase e1 component deficiency (pdhe1 deficiency)		0.0	1.0
Transfer of acetyl groups into mitochondria		0.0	1.0
Adrenal hyperplasia type 3 or congenital adrenal hyperplasia due to 21-hydroxylase deficiency		0.0	1.0
Hypoacetylaspartia		0.0	1.0
4-hydroxybutyric aciduria/succinic semialdehyde dehydrogenase deficiency		0.0	1.0
Hyperinsulinism-hyperammonemia syndrome		0.0	1.0
Intracellular signalling through histamine h2 receptor and histamine		0.0	1.0
Molybdenium cofactor deficiency		0.0	1.0
Gliclazide pathway		0.0	1.0
Hyperprolinemia type i		0.0	1.0
5-oxoprolinuria		0.0	1.0
Phenylketonuria		0.0	1.0
Tenofovir pathway		0.0	1.0
Tamoxifen pathway		0.0	1.0
Guanidinoacetate methyltransferase deficiency (gamt deficiency)		0.0	1.0
Glibenclamide pathway		0.0	1.0
Citalopram pathway		0.0	1.0
Congenital bile acid synthesis defect type iii		0.0	1.0
Excitatory neural signalling through 5-htr 7 and serotonin		0.0	1.0
3-methylglutaconic aciduria type iii		0.0	1.0
Fluorouracil pathway		0.0	1.0
Betaine metabolism		0.0	1.0
Phenprocoumon pathway		0.0	1.0
Repaglinide pathway		0.0	1.0
Steroidogenesis		0.0	1.0
Sialuria or french type sialuria		0.0	1.0
Retinol metabolism		0.0	1.0
Sarcosinemia		0.0	1.0
Congenital erythropoietic porphyria (cep) or gunther disease		0.0	1.0
Lesch-nyhan syndrome (lns)		0.0	1.0
Galactose metabolism		0.0	1.0
Phospholipid biosynthesis		0.0	1.0
Histidine metabolism		0.0	1.0
Insulin signalling		0.0	1.0
Hawkinsinuria		0.0	1.0
Paclitaxel pathway		0.0	1.0
2-hydroxyglutric aciduria (d and l form)		0.0	1.0
Gout or kelley-seegmiller syndrome		0.0	1.0
Glycerol kinase deficiency		0.0	1.0
Argininemia		0.0	1.0
Spermidine and spermine biosynthesis		0.0	1.0
Biotinidase deficiency		0.0	1.0
Degradation of superoxides		0.0	1.0
Intracellular signalling through prostacyclin receptor and prostacyclin		0.0	1.0
Primary hyperoxaluria type i		0.0	1.0
Citrullinemia type i		0.0	1.0
Selenoamino acid metabolism		0.0	1.0
Eplerenone pathway		0.0	1.0
Nicotinate and nicotinamide metabolism		0.0	1.0
Fatty acid metabolism		0.0	1.0
Mngie (mitochondrial neurogastrointestinal encephalopathy)		0.0	1.0
Galactosemia		0.0	1.0
Excitatory neural signalling through 5-htr 4 and serotonin		0.0	1.0
2-methyl-3-hydroxybutryl coa dehydrogenase deficiency		0.0	1.0
Glucose transporter defect (sglt2)		0.0	1.0
Pyruvaldehyde degradation		0.0	1.0
Dihydropyrimidinase deficiency		0.0	1.0
Canavan disease		0.0	1.0
Glutathione synthetase deficiency		0.0	1.0
Spironolactone pathway		0.0	1.0
Beta-alanine metabolism		0.0	1.0
Dimethylglycine dehydrogenase deficiency		0.0	1.0
Lysine degradation		0.0	1.0
Vincristine pathway		0.0	1.0
S-adenosylhomocysteine (sah) hydrolase deficiency		0.0	1.0
Tryptophan metabolism		0.0	1.0
Iminoglycinuria		0.0	1.0
Adrenal hyperplasia type 5 or congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency		0.0	1.0
Warfarin pathway		0.0	1.0
Biotin metabolism		0.0	1.0
Ketone body metabolism		0.0	1.0
Leigh syndrome		0.0	1.0
Arachidonic acid metabolism		0.0	1.0
Isovaleric aciduria		0.0	1.0
Tyrosine metabolism		0.0	1.0
Inositol metabolism		0.0	1.0
Butyrate metabolism		0.0	1.0
Vitamin k metabolism		0.0	1.0
Vitamin a deficiency		0.0	1.0
Aromatic l-aminoacid decarboxylase deficiency		0.0	1.0
Alanine metabolism		0.0	1.0
Gamma-glutamyltransferase deficiency		0.0	1.0
Starch and sucrose metabolism		0.0	1.0
Fatty acid biosynthesis		0.0	1.0
17-beta hydroxysteroid dehydrogenase iii deficiency		0.0	1.0
Methylmalonic aciduria		0.0	1.0
Arginine and proline metabolism		0.0	1.0
Fluoxetine pathway		0.0	1.0
Alkaptonuria		0.0	1.0
Gaba-transaminase deficiency		0.0	1.0
Cystathionine beta-synthase deficiency		0.0	1.0
Congenital lipoid adrenal hyperplasia (clah) or lipoid cah		0.0	1.0
Dicumarol pathway		0.0	1.0
Lactose intolerance		0.0	1.0
Intracellular signalling through adenosine receptor a2a and adenosine		0.0	1.0
Bile acid biosynthesis		0.0	1.0
Malate-aspartate shuttle		0.0	1.0
Propanoate metabolism		0.0	1.0
Saccharopinuria/hyperlysinemia ii		0.0	1.0
Phenylalanine and tyrosine metabolism		0.0	1.0
Beta ureidopropionase deficiency		0.0	1.0
Phytanic acid peroxisomal oxidation		0.0	1.0
Malonic aciduria		0.0	1.0
Vindesine pathway		0.0	1.0
Docetaxel pathway		0.0	1.0
Porphyria variegata (pv)		0.0	1.0
Glutaric aciduria type iii		0.0	1.0
Dihydropyrimidine dehydrogenase deficiency (dhpd)		0.0	1.0
Prolinemia type ii		0.0	1.0
Carnitine synthesis		0.0	1.0
Glycogen storage disease type 1a (gsd1a) or von gierke ddisease		0.0	1.0
Valine, leucine and isoleucine degradation		0.0	1.0
Child syndrome		0.0	1.0
Beta-ketothiolase deficiency		0.0	1.0
Purine metabolism		0.0	1.0
Vitamin b6 metabolism		0.0	1.0
Methylmalonate semialdehyde dehydrogenase deficiency		0.0	1.0
Obesity / metabolic syndrome		0.0	1.0
D-arginine and d-ornithine metabolism		0.0	1.0
Pyruvate carboxylase deficiency		0.0	1.0
Homocysteine degradation		0.0	1.0
Xanthine dehydrogenase deficiency (xanthinuria)		0.0	1.0
Chondrodysplasia punctata ii, x linked dominant (cdpx2)		0.0	1.0
Desipramine pathway		0.0	1.0
Pyruvate metabolism		0.0	1.0
Capecitabine pathway		0.0	1.0
Intracellular signalling through lhcgr receptor and luteinizing hormone/choriogonadotropin		0.0	1.0
Aspartate metabolism		0.0	1.0
Salla disease/infantile sialic acid storage disease		0.0	1.0
Pyrimidine metabolism		0.0	1.0
Methionine adenosyltransferase deficiency		0.0	1.0
Gluconeogenesis		0.0	1.0
Ump synthase deiciency (orotic aciduria)		0.0	1.0
Inositol phosphate metabolism		0.0	1.0
Gaucher disease		0.0	1.0
Nateglinide pathway		0.0	1.0
Methylmalonic aciduria due to cobalamin-related disorders		0.0	1.0
Renal glucosuria		0.0	1.0
2-oxobutanoate degradation		0.0	1.0
Ornithine aminotransferase deficiency (oat deficiency)		0.0	1.0
Hereditary coproporphyria (hcp)		0.0	1.0
Glucose-alanine cycle		0.0	1.0
Hartnup disorder		0.0	1.0
Ornithine transcarbamylase deficiency (otc deficiency)		0.0	1.0
Vinorelbine pathway		0.0	1.0
Sulfate/sulfite metabolism		0.0	1.0
Mitochondrial electron transport chain		0.0	1.0
Lactose degradation		0.0	1.0
Transcription/translation		0.0	1.0
Refsum disease		0.0	1.0
Imipramine pathway		0.0	1.0
Vasopressin regulation of water homeostasis		0.0	1.0

Pathway	hits	oddsratio	pvalue
Lactose synthesis		0.0	1.0
Intracellular signalling through pgd2 receptor and prostaglandin d2		0.0	1.0
Glycine n-methyltransferase deficiency		0.0	1.0
3-methylglutaconic aciduria type i		0.0	1.0
Oxidation of branched chain fatty acids		0.0	1.0
Caffeine metabolism		0.0	1.0
Glycerol phosphate shuttle		0.0	1.0
Pentose phosphate pathway		0.0	1.0
Sphingolipid metabolism		0.0	1.0
Tyrosinemia type 3 (tyro3)		0.0	1.0
Excitatory neural signalling through 5-htr 6 and serotonin		0.0	1.0
Nucleotide sugars metabolism		0.0	1.0
Fructose and mannose degradation		0.0	1.0
3-hydroxy-3-methylglutaryl-coa lyase deficiency		0.0	1.0
Ethylmalonic encephalopathy		0.0	1.0
Aspartylglucosaminuria		0.0	1.0
Vinblastine pathway		0.0	1.0
Alpha linolenic acid and linoleic acid metabolism		0.0	1.0
Adefovir dipivoxil pathway		0.0	1.0
Aica-ribosiduria		0.0	1.0
Fatty acid elongation in mitochondria		0.0	1.0
Amino sugar metabolism		0.0	1.0
Escitalopram pathway		0.0	1.0
Ethanol degradation		0.0	1.0
Androgen and estrogen metabolism		0.0	1.0
Lactic acidemia		0.0	1.0
Lysinuric protein intolerance		0.0	1.0
Glutaric aciduria type i		0.0	1.0
Riboflavin metabolism		0.0	1.0
Non ketotic hyperglycinemia		0.0	1.0
Phosphatidylinositol phosphate metabolism		0.0	1.0
Propionic acidemia		0.0	1.0
Globoid cell leukodystrophy		0.0	1.0
Hyperprolinemia type ii		0.0	1.0
Glycolysis		0.0	1.0
Hypermethioninemia		0.0	1.0
Sialidosis		0.0	1.0
Glycine, serine and threonine metabolism		0.0	1.0
Ammonia recycling		0.0	1.0
Familial hypercholanemia (fhca)		0.0	1.0
Nicotine pathway		0.0	1.0
Thiamine metabolism		0.0	1.0
Cysteine metabolism		0.0	1.0
Urea cycle		0.0	1.0
Steroid biosynthesis		0.0	1.0
Purine nucleoside phosphorylase deficiency		0.0	1.0
Pyruvate dehydrogenase complex deficiency		0.0	1.0
Ubiquinone biosynthesis		0.0	1.0
Catecholamine biosynthesis		0.0	1.0
Arginine: glycine amidinotransferase deficiency (agat deficiency)		0.0	1.0
Prolidase deficiency(pd)		0.0	1.0
Acute intermittent porphyria		0.0	1.0
Methionine metabolism		0.0	1.0
Adenosine deaminase deficiency		0.0	1.0
Acenocoumarol pathway		0.0	1.0
Smith-lemli-opitz syndrome (slos)		0.0	1.0
Phenylacetate metabolism		0.0	1.0
Cerebrotendinous xanthomatosis (ctx)		0.0	1.0
Beta oxidation of very long chain fatty acids		0.0	1.0
Corticotropin activation of cortisol production		0.0	1.0
Citric acid cycle		0.0	1.0
Glutamate metabolism		0.0	1.0
Intracellular signalling through fsh receptor and follicle stimulating hormone		0.0	1.0
Short chain acyl coa dehydrogenase deficiency (scad deficiency)		0.0	1.0
Zellweger syndrome		0.0	1.0
Argininosuccinic aciduria		0.0	1.0
Glycerolipid metabolism		0.0	1.0
Maple syrup urine disease		0.0	1.0
Leukotriene c4 synthesis deficiency		0.0	1.0
One carbon pool by folate		0.0	1.0
Nebivolol pathway		0.0	1.0
Taurine and hypotaurine metabolism		0.0	1.0
Desmosterolosis		0.0	1.0
Tyrosinemia type i		0.0	1.0
3-methylglutaconic aciduria type iv		0.0	1.0
Adenylosuccinate lyase deficiency		0.0	1.0
Intracellular signalling through adenosine receptor a2b and adenosine		0.0	1.0
Lysosomal acid lipase deficiency (wolman disease)		0.0	1.0
Folate and pterine biosynthesis		0.0	1.0
Tyrosinemia type 2 (or richner-hanhart syndrome)		0.0	1.0
Pantothenate and coa biosynthesis		0.0	1.0
Histidinemia		0.0	1.0
Congenital bile acid synthesis defect type ii		0.0	1.0
Methylenetetrahydrofolate reductase deficiency (mthfrd)		0.0	1.0
Metachromatic leukodystrophy (mld)		0.0	1.0
3-methylcrotonyl coa carboxylase deficiency type i		0.0	1.0
Glutathione metabolism		0.0	1.0
Pyruvate decarboxylase e1 component deficiency (pdhe1 deficiency)		0.0	1.0
Transfer of acetyl groups into mitochondria		0.0	1.0
Adrenal hyperplasia type 3 or congenital adrenal hyperplasia due to 21-hydroxylase deficiency		0.0	1.0
Hypoacetylaspartia		0.0	1.0
4-hydroxybutyric aciduria/succinic semialdehyde dehydrogenase deficiency		0.0	1.0
Hyperinsulinism-hyperammonemia syndrome		0.0	1.0
Intracellular signalling through histamine h2 receptor and histamine		0.0	1.0
Molybdenium cofactor deficiency		0.0	1.0
Gliclazide pathway		0.0	1.0
Hyperprolinemia type i		0.0	1.0
5-oxoprolinuria		0.0	1.0
Phenylketonuria		0.0	1.0
Tenofovir pathway		0.0	1.0
Tamoxifen pathway		0.0	1.0
Guanidinoacetate methyltransferase deficiency (gamt deficiency)		0.0	1.0
Glibenclamide pathway		0.0	1.0
Citalopram pathway		0.0	1.0
Congenital bile acid synthesis defect type iii		0.0	1.0
Excitatory neural signalling through 5-htr 7 and serotonin		0.0	1.0
3-methylglutaconic aciduria type iii		0.0	1.0
Fluorouracil pathway		0.0	1.0
Betaine metabolism		0.0	1.0
Phenprocoumon pathway		0.0	1.0
Repaglinide pathway		0.0	1.0
Steroidogenesis		0.0	1.0
Sialuria or french type sialuria		0.0	1.0
Retinol metabolism		0.0	1.0
Sarcosinemia		0.0	1.0
Congenital erythropoietic porphyria (cep) or gunther disease		0.0	1.0
Lesch-nyhan syndrome (lns)		0.0	1.0
Galactose metabolism		0.0	1.0
Phospholipid biosynthesis		0.0	1.0
Histidine metabolism		0.0	1.0
Insulin signalling		0.0	1.0
Hawkinsinuria		0.0	1.0
Paclitaxel pathway		0.0	1.0
2-hydroxyglutric aciduria (d and l form)		0.0	1.0
Gout or kelley-seegmiller syndrome		0.0	1.0
Glycerol kinase deficiency		0.0	1.0
Argininemia		0.0	1.0
Spermidine and spermine biosynthesis		0.0	1.0
Biotinidase deficiency		0.0	1.0
Degradation of superoxides		0.0	1.0
Intracellular signalling through prostacyclin receptor and prostacyclin		0.0	1.0
Primary hyperoxaluria type i		0.0	1.0
Citrullinemia type i		0.0	1.0
Selenoamino acid metabolism		0.0	1.0
Eplerenone pathway		0.0	1.0
Nicotinate and nicotinamide metabolism		0.0	1.0
Fatty acid metabolism		0.0	1.0
Mngie (mitochondrial neurogastrointestinal encephalopathy)		0.0	1.0
Galactosemia		0.0	1.0
Excitatory neural signalling through 5-htr 4 and serotonin		0.0	1.0
2-methyl-3-hydroxybutryl coa dehydrogenase deficiency		0.0	1.0
Glucose transporter defect (sglt2)		0.0	1.0
Pyruvaldehyde degradation		0.0	1.0
Dihydropyrimidinase deficiency		0.0	1.0
Canavan disease		0.0	1.0
Glutathione synthetase deficiency		0.0	1.0
Spironolactone pathway		0.0	1.0
Beta-alanine metabolism		0.0	1.0
Dimethylglycine dehydrogenase deficiency		0.0	1.0
Lysine degradation		0.0	1.0
Vincristine pathway		0.0	1.0
S-adenosylhomocysteine (sah) hydrolase deficiency		0.0	1.0
Tryptophan metabolism		0.0	1.0
Iminoglycinuria		0.0	1.0
Adrenal hyperplasia type 5 or congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency		0.0	1.0
Warfarin pathway		0.0	1.0
Biotin metabolism		0.0	1.0
Ketone body metabolism		0.0	1.0
Leigh syndrome		0.0	1.0
Arachidonic acid metabolism		0.0	1.0
Isovaleric aciduria		0.0	1.0
Tyrosine metabolism		0.0	1.0
Inositol metabolism		0.0	1.0
Butyrate metabolism		0.0	1.0
Vitamin k metabolism		0.0	1.0
Vitamin a deficiency		0.0	1.0
Aromatic l-aminoacid decarboxylase deficiency		0.0	1.0
Alanine metabolism		0.0	1.0
Gamma-glutamyltransferase deficiency		0.0	1.0
Starch and sucrose metabolism		0.0	1.0
Fatty acid biosynthesis		0.0	1.0
17-beta hydroxysteroid dehydrogenase iii deficiency		0.0	1.0
Methylmalonic aciduria		0.0	1.0
Arginine and proline metabolism		0.0	1.0
Fluoxetine pathway		0.0	1.0
Alkaptonuria		0.0	1.0
Gaba-transaminase deficiency		0.0	1.0
Cystathionine beta-synthase deficiency		0.0	1.0
Congenital lipoid adrenal hyperplasia (clah) or lipoid cah		0.0	1.0
Dicumarol pathway		0.0	1.0
Lactose intolerance		0.0	1.0
Intracellular signalling through adenosine receptor a2a and adenosine		0.0	1.0
Bile acid biosynthesis		0.0	1.0
Malate-aspartate shuttle		0.0	1.0
Propanoate metabolism		0.0	1.0
Saccharopinuria/hyperlysinemia ii		0.0	1.0
Phenylalanine and tyrosine metabolism		0.0	1.0
Beta ureidopropionase deficiency		0.0	1.0
Phytanic acid peroxisomal oxidation		0.0	1.0
Malonic aciduria		0.0	1.0
Vindesine pathway		0.0	1.0
Docetaxel pathway		0.0	1.0
Porphyria variegata (pv)		0.0	1.0
Glutaric aciduria type iii		0.0	1.0
Dihydropyrimidine dehydrogenase deficiency (dhpd)		0.0	1.0
Prolinemia type ii		0.0	1.0
Carnitine synthesis		0.0	1.0
Glycogen storage disease type 1a (gsd1a) or von gierke ddisease		0.0	1.0
Valine, leucine and isoleucine degradation		0.0	1.0
Child syndrome		0.0	1.0
Beta-ketothiolase deficiency		0.0	1.0
Purine metabolism		0.0	1.0
Vitamin b6 metabolism		0.0	1.0
Methylmalonate semialdehyde dehydrogenase deficiency		0.0	1.0
Obesity / metabolic syndrome		0.0	1.0
D-arginine and d-ornithine metabolism		0.0	1.0
Pyruvate carboxylase deficiency		0.0	1.0
Homocysteine degradation		0.0	1.0
Xanthine dehydrogenase deficiency (xanthinuria)		0.0	1.0
Chondrodysplasia punctata ii, x linked dominant (cdpx2)		0.0	1.0
Desipramine pathway		0.0	1.0
Pyruvate metabolism		0.0	1.0
Capecitabine pathway		0.0	1.0
Intracellular signalling through lhcgr receptor and luteinizing hormone/choriogonadotropin		0.0	1.0
Aspartate metabolism		0.0	1.0
Salla disease/infantile sialic acid storage disease		0.0	1.0
Pyrimidine metabolism		0.0	1.0
Methionine adenosyltransferase deficiency		0.0	1.0
Gluconeogenesis		0.0	1.0
Ump synthase deiciency (orotic aciduria)		0.0	1.0
Inositol phosphate metabolism		0.0	1.0
Gaucher disease		0.0	1.0
Nateglinide pathway		0.0	1.0
Methylmalonic aciduria due to cobalamin-related disorders		0.0	1.0
Renal glucosuria		0.0	1.0
2-oxobutanoate degradation		0.0	1.0
Ornithine aminotransferase deficiency (oat deficiency)		0.0	1.0
Hereditary coproporphyria (hcp)		0.0	1.0
Glucose-alanine cycle		0.0	1.0
Hartnup disorder		0.0	1.0
Ornithine transcarbamylase deficiency (otc deficiency)		0.0	1.0
Vinorelbine pathway		0.0	1.0
Sulfate/sulfite metabolism		0.0	1.0
Mitochondrial electron transport chain		0.0	1.0
Lactose degradation		0.0	1.0
Transcription/translation		0.0	1.0
Refsum disease		0.0	1.0
Imipramine pathway		0.0	1.0
Vasopressin regulation of water homeostasis		0.0	1.0